Kathryn C. Stallcup - Boston MA Matthew F. Mescher - Del Mar CA Steven J. Burakoff - West Newton MA
President and Fellows of Harvard College - Cambridge MA
A61K 3512 A61K 35413
A purified growth inhibitory factor comprising a lipid-like compound derived from or substantially similar to the factor present in lymphocyte or liver cell plasma membranes is capable of inhibiting cytolytic T-lymphocyte killing response and mitogen-induced B cell, T cell, or lymphoid tumor cell proliferation.
Immunization and/or therapeutic in vivo introduction of ligands bound alone or in combination with other molecules, arrayed on solid supports having greater then about 0. 2. mu. diameter to elicit and augment in vivo T cell mediated responses are described.