Matthew R Dreher

US Patent:

20070009602, Jan 11, 2007

Filed:

Jun 21, 2006

Appl. No.:

11/472113

Inventors:

Lori Setton - Durham NC, US
Ashutosh Chilkoti - Durham NC, US
Virginia Kraus - Hillsborough NC, US
Helawe Betre - Durham NC, US
Matthew Dreher - Durham NC, US

International Classification:

A61K 39/395
A61K 9/14
A61M 31/00

US Classification:

424486000, 424145100, 424078270, 604500000

Abstract:

A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

US Patent:

20100189643, Jul 29, 2010

Filed:

Jul 17, 2007

Appl. No.:

12/374816

Inventors:

Ashutosh Chilkoti - Durham NC, US
Matthew Robert Dreher - Durham NC, US
Daniel Eugene Meyer - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

A61K 47/48
A61K 49/00
A61K 51/00

US Classification:

424 165, 530402, 5303917, 424 91

Abstract:

The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.

US Patent:

20110110866, May 12, 2011

Filed:

Apr 10, 2008

Appl. No.:

12/082271

Inventors:

Ashutosh Chilkoti - Durham NC, US
Matthew R. Dreher - Rockville MD, US
Daniel E. Meyer - Rexford NY, US
Mark W. Dewhirst - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 49/14
C07K 14/00
A61P 35/00
A61P 9/10

US Classification:

424 934, 530400, 428402

Abstract:

A magnetic resonance imaging (MRI) contrast enhancement agent comprising an elastin-like polypeptide (ELP) and one or more paramagnetic metal ions is disclosed. Also disclosed are methods of preparing ELP MRI contrast enhancement agents, formulations comprising ELP MRI contrast enhancement agents, and methods of using ELP MRI contrast enhancement agents to image biological samples and to image and deliver therapeutic agents to targeted sites in vivo. In some embodiments, the ELP MRI agents can be used in methods related to blood volume determination, in magnetic resonance angiography (MRA), and in vascular transport determinations. The ELP MRI contrast agents can also provide information on the expression of various proteins through affinity targeting or enzymatic crosslinking in order to aid in diagnosis and in the spatial definition of pathologic tissue.

US Patent:

20110200528, Aug 18, 2011

Filed:

Jun 15, 2009

Appl. No.:

13/000543

Inventors:

Bradford J. Wood - Potomac MD, US
Matthew Dreher - Rockville MD, US
Ayele H. Negussie - Rockville MD, US

International Classification:

A61K 49/00
C07K 7/64
A61K 38/12
A61K 9/127

US Classification:

424 91, 530321, 514 211, 424450

Abstract:

Cyclized peptide compounds containing the NGR motif of formula (I) or a pharmaceutically-acceptable salt thereof are disclosed. Compositions comprising the cyclized peptide compounds and methods of their use are also disclosed.

US Patent:

20110207673, Aug 25, 2011

Filed:

Nov 20, 2008

Appl. No.:

12/743990

Inventors:

Ashutosh Chilkoti - Durham NC, US
John A. Mackay - Durham NC, US
Matthew R. Dreher - Durham NC, US

International Classification:

A61K 38/16
A61P 35/00
C07K 1/113

US Classification:

514 193, 514 11, 514 212, 530402, 514 209

Abstract:

Drug-polymer chemotherapeutics are provided having improved therapeutic efficacy and reduced dose-limiting toxicity. Methods are also provided for modulating the architecture, pharmacokinetics and biodistribution of drug-polymers and for reducing the dependence of transition temperature on concentration for drug-polymers.

US Patent:

20110236384, Sep 29, 2011

Filed:

Jan 24, 2011

Appl. No.:

13/012475

Inventors:

Lori A. SETTON - Durham NC, US
Ashutosh Chilkoti - Durham NC, US
Virginia B. Kraus - Hillsborough NC, US
Helawe Betre - Durham NC, US
Matthew R. Dreher - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 38/16
A61K 39/395
A61P 19/02

US Classification:

4241341, 514 212, 514 167, 514 168

Abstract:

A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

US Patent:

20130217950, Aug 22, 2013

Filed:

Oct 11, 2011

Appl. No.:

13/879412

Inventors:

Ari Ilkka Mikael Partanen - Bethesda MD, US
Matthew Robert Dreher - Rockville MD, US
Pavel Sergeyevich Yarmolenko - Silver Spring MD, US
Antti Johannes Viitala - Espoo, FI
Julia Kristina Enholm - Helsingfors, FI
Max Oskar Kohler - Espoo, FI

Assignee:

NATIONAL INSTITUTES OF HEALTH - Bethesda MD
KONINKLIJKE PHILIPS ELECTRONICS N.V. - EINDHOVEN

International Classification:

A61N 7/00

US Classification:

600 1, 601 2

Abstract:

A therapeutic apparatus () comprising a high intensity focused ultrasound system () for heating a target zone (). The therapeutic apparatus further comprises a magnetic resonance imaging system (). The therapeutic apparatus further comprises a memory () containing machine executable instructions () for execution by a processor (). Execution of the instructions cause the processor to: generate () heating commands () which cause the high intensity focused ultrasound system to sonicate the subject; repeatedly acquire () magnetic resonance data () during execution of the heating commands; repeatedly calculate () a spatially dependent parameter (); and repeatedly modify () the heating commands in accordance with the spatially dependent parameter such that within the target zone the spatially dependent parameter remains below a first predetermined threshold and above a second predetermined threshold.

US Patent:

20130345559, Dec 26, 2013

Filed:

Mar 28, 2013

Appl. No.:

13/852897

Inventors:

Matthew R. DREHER - Rockville MD, US
Karun V. SHARMA - McLean VA, US
Bradford J. WOOD - Bethesda MD, US

Assignee:

MUSC FOUNDATION FOR RESEACH DEVELOPMENT - Charleston SC

International Classification:

A61B 5/0275

US Classification:

600431

Abstract:

Methods for quantitative perfusion analysis for embolotherapy are presented. The method quantitatively measures blood flow changes based on angiographic information. The method may provide potential evaluation of optimal embolization endpoints in vascular vessels. The method may be used in various applications such as transcatheter arterial chemoembolization (TACE), or other medical procedures that affect blow flow within bodily tissues. The method is applicable towards treatment of tumors in liver, kidney, brain, and other organs.