Matthew Anderson

US Patent:

20120029062, Feb 2, 2012

Filed:

Aug 2, 2011

Appl. No.:

13/136498

Inventors:

Preethi H. Gunaratne - Houston TX, US
Lalithya C. Jayarathne - Houston TX, US
Matthew L. Anderson - Houston TX, US

International Classification:

A61K 31/7088
C12N 5/02
A61P 35/00
C07H 21/04
C07H 21/02
C07F 1/12
C12Q 1/02
A61K 31/28

US Classification:

514 44 R, 435 29, 435375, 514495, 536 231, 536 245, 556 28, 556111

Abstract:

Provided herein are nanoparticle platforms and combinatorial drug delivery vehicles comprising gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment.

US Patent:

20130065949, Mar 14, 2013

Filed:

Oct 14, 2010

Appl. No.:

13/501806

Inventors:

Martin M. Matzuk - Houston TX, US
Chad Creighton - Houston TX, US
Zhifeng Yu - Houston TX, US
Michael Fountain - Houston TX, US
Preethi Gunaratne - Houston TX, US
Matthew A. Anderson - Houston TX, US

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

A61K 31/7088
A61P 35/00

US Classification:

514 44 R

Abstract:

The present invention generally concerns methods and compositions for treating and/or preventing cancer with microRNAs. In specific embodiments, the present invention encompasses a particular microRNA, microRNA-31, as useful in cancer therapy and/or prevention. Specific cancers may be treated, including at least ovarian, prostate, urothelial, osteosarcoma, and glioblastoma.

US Patent:

20130089597, Apr 11, 2013

Filed:

Apr 2, 2012

Appl. No.:

13/437251

Inventors:

Preethi H. Gunaratne - Houston TX, US
Ashley L. Benham - Kingwood TX, US
Matthew L. Anderson - Houston TX, US

International Classification:

A61K 31/713
A61K 9/127
A61K 33/24

US Classification:

424450, 514 44 A, 424649, 536 245, 506 16, 435 612, 506 9, 536 2431

Abstract:

The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-130 or an agent that mimics the effects of microRNA-130. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-130 or an agent that enhances the expression of microRNA-130.

US Patent:

20140128451, May 8, 2014

Filed:

Oct 21, 2013

Appl. No.:

14/059027

Inventors:

Preethi H Gunaratne - Houston TX, US
Lalithya C Singh - Houston TX, US
Matthew L Anderson - Houston TX, US

International Classification:

A61K 31/7105
A61K 47/48

US Classification:

514 44 A, 536 245

Abstract:

Provided herein are gold nanoparticles mediated non-viral delivery of miRNAs, siRNAs, genes and drugs. Nanoparticle platforms and combinatorial drug delivery vehicles comprises gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Successful manipulation of the degree of PEGylation and the amount of gold nanoparticles in a polyelectrolyte complex to evaluate the best formulation for highest payload delivery of chemically unmodified miRNA duplexes and stemloops is presented. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment.

Address:

3115 Amerson Dr, Pearland, TX 77584

Phone:

281-489-0789

VIN:

3GNEC12JX7G139820

Make:

CHEVROLET

Model:

AVALANCHE

Year:

2007