Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to either a pyroglutamate moiety, a pyrrolidinone moiety, or a gentisic acid moiety.
Yuehua Zhang - Mill Creek WA, US Manjari Lal - Bellevue WA, US Andrew Leo - Kirkland WA, US Nagesh Palepu - Mill Creek WA, US
Assignee:
Sonus Pharmaceuticals, Inc. - Bothell WA
International Classification:
C07C069/34
US Classification:
560197, 560192, 564123, 564192, 564193, 564199
Abstract:
Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one embodiment, the fluorinated compound is a vitamin K derivative.
Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for using the platinum compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
Yuehua Zhang - Mill Creek WA, US Manjari Lal - Bellevue WA, US Andrew Leo - Kirkland WA, US Nagesh Palepu - Mill Creek WA, US
Assignee:
Sonus Pharmaceuticals, Inc. - Bothell WA
International Classification:
C07C 231/00
US Classification:
560129, 564156, 564160, 568681, 568683
Abstract:
Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one embodiment, the fluorinated compound is a vitamin K derivative.
Platinum carboxylate anticancer compounds, pharmaceutical compositions that include the platinum carboxylate compounds, and methods for treating cellular proliferative diseases by administering the platinum carboxylate compounds.
Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for using the platinum compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
Manjari Lal - Redmond WA, US Lynn C. Gold - Seattle WA, US
Assignee:
Sonus Pharmaceuticals, Inc. - Bothell WA
International Classification:
C07F 15/00 A61K 31/28
US Classification:
556137, 514492
Abstract:
Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds.
Yuehua Zhang - Mill Creek WA, US Manjari Lal - Bellevue WA, US Nagesh Palepu - Mill Creek WA, US
Assignee:
Sonus Pharmaceuticals, Inc.
International Classification:
A61K031/355 C 07D 4 5/14
US Classification:
514/458000, 549/408000
Abstract:
Tocopherol derivatives are provided. In one embodiment, the tocopherol derivative includes a tocopherol moiety covalently coupled to branched hydrophilic moiety. In another embodiment, the tocopherol derivative includes a first tocopherol moiety covalently coupled to a second tocopherol moiety through a hydrophilic moiety. In other embodiments, the derivative includes three or more tocopherol moieties.
Resumes
Program Advisor Formulation Technologies For Vaccines And Drugs
Path
Program Advisor Formulation Technologies For Vaccines and Drugs
Path Dec 2017 - Jul 2019
Portfolio Leader Formulation Technologies
Path Dec 2017 - Jul 2019
Senior Research Officer
Path Dec 2017 - Jul 2019
Technical Officer
Sonus Pharma Nov 2000 - Mar 2008
Research Scientist Iii
Education:
State University of New York College at Buffalo
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