Mahendra S Pawar

US Patent:

20100166857, Jul 1, 2010

Filed:

Dec 30, 2009

Appl. No.:

12/649943

Inventors:

Dong Yan - Palo Alto CA, US
Lee Foong Siew - Dublin CA, US
Richard Ting - Danville CA, US
Tzu-Yuan Chen - San Jose CA, US
Mahendra Sudhakar Pawar - Santa Rosa CA, US

International Classification:

A61K 9/26
A61K 9/50
A61K 31/216
A61P 9/10
A61P 3/06
B05D 1/02

US Classification:

424465, 424494, 424497, 514543, 427 215

Abstract:

The invention provides solid dispersions of at least one insoluble active pharmaceutical ingredient, pharmaceutical dosage forms comprising the solid dispersions, and methods of manufacturing same. In an embodiment, a solid dispersion of the present invention includes a plurality of coated particles comprising inert particles with a coating, wherein the coating comprises an insoluble active pharmaceutical ingredient dispersed in a hydrophilic polymer, and wherein the inert particles comprise nonpareils; and a plurality of granules comprising an insoluble active pharmaceutical ingredient with at least one pharmaceutically acceptable excipient. In an embodiment, the insoluble active pharmaceutical ingredient in the coating and the insoluble active pharmaceutical ingredient of the granules are the same type. A solid dispersion of the present invention may optionally be encapsulated in capsules or compressed into a tablet. Also disclosed are methods of making solid dispersions and methods of reducing plasma triglyceride and increasing high-density lipoprotein employing the solid dispersion.