Lisa A Cowen

US Patent:

48408948, Jun 20, 1989

Filed:

Mar 4, 1986

Appl. No.:

6/835898

Inventors:

David Schachter - Bronx NY
Szloma Kowarski - Bronx NY
Lisa A. Cowen - New York NY
Richard E. Abbott - Englewood NJ

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

G01N 3353
G01N 33543
G01N 33555
G01N 33577

US Classification:

435 7

Abstract:

A method for detecting the presence in a human of an integral membrane calcium-binding protein associated with essential hypertension which comprises isolating tissue from a human, treating the tissue to obtain integral membrane proteins, contacting the proteins thus obtained with a first antibody molecule which binds to the integral membrane calcium binding protein to form an detectable protein-antibody complex, and detecting the complex so formed. Further, methods for quantitatively determining the amount of an integral membrane calcium-binding protein and the messenger RNA encoding said protein, diagnostic methods for identifying individuals predisposed to essential hypertension, and protein and messenger RNA associated with said hypertension.