Lionel C Sevrain

US Patent:

7008427, Mar 7, 2006

Filed:

May 25, 2001

Appl. No.:

10/296392

Inventors:

Lionel C. Sevrain - West Palm Beach FL, US

Assignee:

OrthoPlex, LLC - Boston MA

International Classification:

A61F 2/44
A61B 17/80

US Classification:

606 71, 623 1713

Abstract:

A disc prosthesis for use on a pair of adjacent vertebrae comprises upper and lower plates adapted to be mounted respectively to adjacent upper and lower vertebrae, typically using screws that extend through holes defined in the upper and lower plates and into the upper and lower vertebrae; a joint mechanism linking the upper and lower plates; and a damping system. The joint mechanism and the damping system are adapted to allow for biased relative movements between the upper and lower vertebrae.

US Patent:

7850983, Dec 14, 2010

Filed:

Feb 5, 2007

Appl. No.:

11/671082

Inventors:

Lionel C. Sevrain - West Palm Beach FL, US

Assignee:

Spinalcyte, LLC - Houston TX

International Classification:

A61F 2/30
A61F 13/00
A61K 9/50

US Classification:

424400, 424422

Abstract:

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living, core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

US Patent:

8298560, Oct 30, 2012

Filed:

May 7, 2010

Appl. No.:

12/775753

Inventors:

Lionel C. Sevrain - West Palm Beach FL, US

Assignee:

Spinalcyte, LLC - Houston TX

International Classification:

A61K 9/50
A61F 2/30
A61F 13/00

US Classification:

424422, 424400

Abstract:

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

US Patent:

8491870, Jul 23, 2013

Filed:

Nov 23, 2008

Appl. No.:

12/809139

Inventors:

Lionel C. Sevrain - West Palm Beach FL, US

Assignee:

Lers Surgical, LLC - West Palm Beach FL

International Classification:

A61K 49/00

US Classification:

424 91

Abstract:

The present invention generally concerns the detection and/or treatment of aneurysm in a non-invasive manner. In particular cases, the invention concerns methods and compositions for localizing a labeled composition to the site of an aneurysm for its detection and, in further cases, treatment of the aneurysm. In specific cases, the composition targets a subendothelial component of the aneurysmal wall, such as a smooth muscle cell exposed at the luminal surface of the vessel. In further specific cases, the composition targets an integrin receptor or laminin.

US Patent:

8501156, Aug 6, 2013

Filed:

Feb 6, 2007

Appl. No.:

12/162424

Inventors:

Lionel C. Sevrain - West Palm Beach FL, US

Assignee:

Lers Surgical, LLC - West Palm Beach FL

International Classification:

A61K 49/00

US Classification:

424 92, 424 111, 424 165, 424 91, 424 96, 206223, 206569

Abstract:

Described herein is a method for non-invasive detection and treatment of intra-cranial aneurysms. Antibodies are provided to specifically react/bind with antigens of the cerebral aneurism wall. The antibodies may be bound to a label and/or to a therapeutic agent for diagnosis and/or for treatment purposes thereof. Intra-cranial aneurysms are thus non-invasively detected before rupture occurs and are specifically treated.

US Patent:

20030135216, Jul 17, 2003

Filed:

Nov 8, 2002

Appl. No.:

10/275710

Inventors:

Lionel Sevrain - Plymouth MA, US

International Classification:

A61B017/58

US Classification:

606/073000, 606/061000, 606/069000

Abstract:

An anchoring system (S) for mounting a support plate (P, P′) for instance to a human rachis comprises first and second threaded fasteners () each having proximal and distal ends. The proximal ends are adapted to be spaced from each other for holding the support plate (P, P′) against a vertebra (V, V, V) of the rachis while the distal ends are embedded in the bone. The threaded fasteners () converge from their proximal ends towards their distal ends. The first threaded fastener () defines at its distal end a female threaded element in the form of a threaded openig () extending obliquely means of the first fastener () and adapted to be threadably engaged by the male threaded distal end of the second fastener (). The proximal end of the first fastener () is provided with indicia for indicating an orientation of its threaded opening () within the bone (V, V, V) such as to facilitate the engagement therein of the male threaded distal end of the second fastener (). With the support plate (P, P′), the first and second facteners () define a triangular frame that is firmly secure to the vertebra (V, V, V).

US Patent:

20030220695, Nov 27, 2003

Filed:

Mar 26, 2003

Appl. No.:

10/396725

Inventors:

Lionel Sevrain - West Palm Beach FL, US

International Classification:

A61F002/44

US Classification:

623/017160

Abstract:

A prosthetic inter-vertebral disc for positioning in an inter-somatic space between a pair of adjacent vertebrae (V) and within a natural annulus fibrosus () or a remaining portion thereof, comprises a flexible elongated outer annulus member () and an expandable inner nucleus member (). The outer annulus member () is adapted to be introduced into the inter-somatic space through a tenotomy opening () and to follow an inside wall of the natural annulus fibrosus () such as to form a closed loop therewithin with the loop defining a chamber (). The inner nucleus member () is adapted to be introduced in a dehydrated state into the inter-somatic space also through the tenotomy opening () and within the outer annulus member (), and to then be hydrated so as to extend in the chamber () peripherally up to the outer annulus member (). Both the outer annulus member () and the inner nucleus member () are hydrogels. The outer annulus member () is biased outwardly when being introduced in the inter-somatic space such that it follows the inside wall of the natural annulus fibrosus (). A free end of the outer annulus member () extends outwardly of the closed loop and into the tenotomy opening for sealing the same. A method of installing the prosthetic disc is also disclosed.

US Patent:

20030229348, Dec 11, 2003

Filed:

Feb 5, 2003

Appl. No.:

10/358398

Inventors:

Lionel Sevrain - West Palm Beach FL, US

International Classification:

A61B017/56

US Classification:

606/070000

Abstract:

A connecting device for use in attaching together at least two adjacent vertebrae comprises upper and lower plate members adapted to be fixedly secured respectively to adjacent upper and lower vertebrae via fasteners, e.g. screws. The upper and lower plate members are provided with respective male and female guide elements that are slidable engaged together so as to allow a relative translational displacement between the upper and lower plate members in response to a similar relative displacement between the upper and lower vertebrae that alters a spacing therebetween. The male guide element comprises longitudinal guide ways, and the female guide element comprises a channel for slidably receiving the male guide element and a pair of side guides extending inwardly and slidably engaged in the guide ways of said male guide element. The female guide element defines a longitudinal slot, and the male guide element comprises a pin extending perpendicularly to a direction of the aforementioned relative displacement and engaged in the slot. A method includes: removing at least part of a disc from an intervertebral space defined between a pair of adjacent vertebrae that include upper and lower vertebrae, and securing first and second plate members respectively to the upper and lower vertebrae, said first and second plate members being capable of relatively displacing for accommodating a change in a distance between the upper and lower vertebrae; wherein a bone graft is positioned in the intervertebral space.