Lifeng Tian

US Patent:

20230048706, Feb 16, 2023

Filed:

Jul 28, 2022

Appl. No.:

17/815647

Inventors:

- Philadelphia PA, US
Dong Li - Drexel Hill PA, US
Lifeng Tian - Wilmington DE, US
Kenny Nguyen - Aberdeen NJ, US
Patrick Sleiman - Philadelphia PA, US

Assignee:

THE CHILDREN'S HOSPITAL OF PHILADELPHIA - Philadelphia PA

International Classification:

C12Q 1/6883
A61P 43/00
A61K 31/4184
A61K 31/436
A61K 31/4427
A61K 31/4709
A61K 31/501
A61K 31/519
A61K 31/5377

Abstract:

Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.

US Patent:

20200056238, Feb 20, 2020

Filed:

Aug 30, 2017

Appl. No.:

16/327060

Inventors:

- Philadelphia PA, US
Dong Li - Drexel Hill PA, US
Lifeng Tian - Wilmington DE, US
Kenny Nguyen - Aberdeen NJ, US
Patrick Sleiman - Philadelphia PA, US

International Classification:

C12Q 1/6883
A61K 31/4184
A61K 31/4427
A61K 31/4709
A61K 31/501
A61K 31/436
A61K 31/519
A61K 31/5377
A61P 43/00

Abstract:

Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.

US Patent:

20180223373, Aug 9, 2018

Filed:

Oct 20, 2017

Appl. No.:

15/788947

Inventors:

- New York NY, US
- Philadelphia PA, US
Lifeng TIAN - Philadelphia PA, US

Assignee:

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - New York NY
THE CHILDREN'S HOSPITAL OF PHILADELPHIA - Philadelphia PA

International Classification:

C12Q 1/6886
A61N 5/00
C12Q 1/6883
A61K 31/506
A61K 45/06

Abstract:

This invention relates to a method of diagnosing a subject as having and/or being a carrier for infantile myofibromatosis. This method involves providing an isolated biological sample from a subject; contacting the sample with one or more reagents suitable for detecting the presence or absence of one or more mutations in PDGFRB and/or NOTCH3; detecting, in the sample, the presence or absence of the one or more mutations in PDGFRB and/or NOTCH3 based on said contacting; and diagnosing the subject as having and/or being a carrier for infantile myofibromatosis based on said detecting, where the presence of the one or more mutations in PDGFRB and/or NOTCH3 indicates the subject has a mutation that causes infantile myofibromatosis. Also disclosed is a method of treating a subject having infantile myofibromatosis and a method of preventing or treating symptoms associated with infantile myofibromatosis.

US Patent:

20160083799, Mar 24, 2016

Filed:

Apr 22, 2014

Appl. No.:

14/786425

Inventors:

- New York NY, US
- Philadelphia PA, US
Lifeng TIAN - Philadelphia PA, US

Assignee:

CHILDREN'S HOSPITAL OF PHILADELPHIA - Philadelphia PA
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - New York NY

International Classification:

C12Q 1/68
A61K 45/06
A61N 5/00
A61K 31/506

Abstract:

This invention relates to a method of diagnosing a subject as having and/or being a carrier for infantile myo fibromatosis. This method involves providing an isolated biological sample from a subject; contacting the sample with one or more reagents suitable for detecting the presence or absence of one or more mutations in PDGFRB and/or NOTCH3; detecting, in the sample, the presence or absence of the one or more mutations in PDGFRB and/or NOTCH3 based on said contacting; and diagnosing the subject as having and/or being a carrier for infantile myofibromatosis based on said detecting, where the presence of the one or more mutations in PDGFRB and/or NOTCH3 indicates the subject has a mutation that causes infantile myofibromatosis. Also disclosed is a method of treating a subject having infantile myofibromatosis and a method of preventing or treating symptoms associated with infantile myofibromatosis.