Nanoparticle coacervates of nucleic acids and polycations serve as effective vaccines when administered orally. They can induce immunity to a variety of disease causing agents and raise a protective response to allergens.
Krishnendu Roy - Baltimore MD Hai-Quan Mao - Towson MD Vu L. Truong - Baltimore MD Thomas August - Baltimore MD Kam W. Leong - Ellicot City MD
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C12N 1500
US Classification:
435455
Abstract:
A gene delivery system is made of enzymatically degradable polymeric cation and nucleic acid (DNA or RNA) nanospheres optionally with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method of coacervation. Targeting ligands can be attached to the nanosphere directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the nanosphere surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.
Iodonium Analogs As Inhibitors Of Nadph Oxidases And Other Flavin Dehydrogenases; Formulations Thereof; And Uses Thereof