Konrad E Huppi

US Patent:

8110352, Feb 7, 2012

Filed:

Feb 10, 2006

Appl. No.:

11/883694

Inventors:

Mark J. Roth - Chevy Chase MD, US
Konrad Huppi - Herndon VA, US

Assignee:

The United States of America as represented by the Secretary, Department of Health & Human Services - Washington DC

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435 61, 435 721, 435 723

Abstract:

The invention relates to method of diagnosing and treating cancer, in particular β-catenin related cancers. The invention further relates to methods of identifying CTNNB1 related cancer CTNNB1 therapeutics.

US Patent:

20120294929, Nov 22, 2012

Filed:

Jan 3, 2012

Appl. No.:

13/342877

Inventors:

Mark J. Roth - Bethesda MD, US
Konrad Huppi - Herndon VA, US

Assignee:

Health & Human Services - NIH - Bethesda MD

International Classification:

G01N 33/574
C12N 15/113
C40B 30/06
A61P 35/00
C12Q 1/68
A61K 31/713
A61K 9/127

US Classification:

424450, 514 44 A, 536 245, 435 612, 435 71, 435 611, 435 614, 435 613, 506 10

Abstract:

The invention relates to method and compositions for treating and diagnosing cancer, in particular β-catenin related cancers. In general, the methods include administering RNAi constructs. The invention further relates to methods of identifying CTNNB1 related cancer therapeutics.

US Patent:

52720578, Dec 21, 1993

Filed:

Oct 14, 1988

Appl. No.:

7/257696

Inventors:

Mark E. Smulson - Washington DC
Kishor Bhatia - Arbutus MD
Konrad Huppi - Reston VA

Assignee:

Georgetown University - Washington DC

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

The invention relates to a method for detecting the presence of a DNA polymorphism associated with predisposition for certain cancers in a human. This method involves analyzing the human chromosome 13 using a hybridization probe which will hybridize to the gene for human poly (ADP-ribose) polymerase wherein the probe is capable of identifying the DNA polymorphism.