Kevin Dykstra

US Patent:

6346526, Feb 12, 2002

Filed:

Jun 23, 1999

Appl. No.:

09/338646

Inventors:

Timothy A. Blizzard - Middletown NJ
Kevin D. Dykstra - West Milford NJ
Ronald W. Ratcliffe - Matawan NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D47714

US Classification:

51421009, 540302

Abstract:

Compounds of formula I: as well as pharmaceutically acceptable salts thereof useful as carbapenem antibacterial agents are disclosed wherein X is CH or C O.

US Patent:

8017605, Sep 13, 2011

Filed:

Jun 10, 2009

Appl. No.:

12/481614

Inventors:

Soumya P. Sahoo - Old Bridge NJ, US
Meng-Hsin Chen - Westfield NJ, US
Kevin D. Dykstra - West Milford NJ, US
Hiroo Koyama - Hoboken NJ, US
Peter T. Meinke - Scotch Plains NJ, US
Stephen J. O'Keefe - Mountainside NJ, US
Ginger Xu-qiang Yang - Jersey City NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/437
A61K 31/519
A61K 31/5025
A61K 31/5377
C07D 471/04
A61P 11/06
A61P 19/00

US Classification:

5142342, 514300, 514303, 5142591, 514248, 546113, 546121, 546118, 544281, 544236, 544127

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:.

US Patent:

8440643, May 14, 2013

Filed:

May 21, 2007

Appl. No.:

12/301797

Inventors:

Frank Dininno - Barnegat NJ, US
Milton L. Hammond - Somerville NJ, US
Kevin Dykstra - West Milford NJ, US
Seongkon Kim - Holmdel NJ, US
Qiang Tan - Westfield NJ, US
Katherine Young - Metuchen NJ, US
Jeffrey Donald Hermes - Warren NJ, US
Helen Chen - Marlboro NJ, US
Stephane Raeppel - St. Lazare, CA
Michael Mannion - Montreal, CA
Frederic Gaudette - Laval, CA
Arkadii Vaisburg - Kirkland, CA
Jubrail Rahil - Dollard des Ormeaux, CA
Nafsika Georgopapadakou - Vaudreuil, CA
Nancy Z. Zhou - Kirkland, CA

Assignee:

MethylGene Inc. - Montreal

International Classification:

A61K 31/675
A61K 31/67
A61K 31/665

US Classification:

514 80, 514 89, 514 92, 514 96, 514100

Abstract:

This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e. g. , imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.

US Patent:

20100317625, Dec 16, 2010

Filed:

May 21, 2007

Appl. No.:

12/301793

Inventors:

Frank Dininno - Barnegat NJ, US
Milton L. Hammond - Somerville NJ, US
Kevin Dykstra - West Milford NJ, US
Seongkon Kim - Holmdel NJ, US
Qiang Tan - Westfield NJ, US
Katherine Young - Metuchen NJ, US
Jeffrey Donald Hermes - Warren NJ, US
Stephane Raeppel - St. Lazare, CA
Michael Mannion - Montreal, CA
Nancy Z. Zhou - Kirkland, CA
Frederic Gaudette - Verdun, CA
Arkadii Vaisburg - Kirkland, CA
Jubrail Rahil - Dollard Des Ormeaux, CA
Nafsika Georgopapadakou - Kirkland, CA

International Classification:

A61K 31/675
C07F 9/6553
A61K 31/67
C07F 9/6561
C07F 9/6539
C07F 9/655
A61K 31/665
A61P 31/04

US Classification:

514 89, 549 6, 514 96, 546 25, 548119, 514 92, 514 95, 549220, 514100

Abstract:

This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.

US Patent:

20110105430, May 5, 2011

Filed:

Jun 8, 2009

Appl. No.:

12/997524

Inventors:

Soumya P. Sahoo - Old Bridge NJ, US
Meng-Hsin Chen - Westfield NJ, US
Kevin D. Dykstra - West Milford NJ, US
Hiroo Koyama - Hoboken NJ, US
Peter T. Meinke - Scotch Plains NJ, US
Stephen J. O'keefe - Mountainside NJ, US
Ginger Xu-Qiang Yang - Jersey City NJ, US

International Classification:

A61K 31/437
C07D 471/04
A61K 31/519
A61K 31/5025
A61K 31/5377
C07F 7/10
A61K 31/695
A61P 29/00
A61P 19/02
A61P 11/06
A61P 11/00

US Classification:

514 63, 546113, 514300, 544281, 5142591, 546118, 514303, 544236, 514248, 546121, 544127, 5142342, 546 14

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors N of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

US Patent:

20110212891, Sep 1, 2011

Filed:

Oct 26, 2009

Appl. No.:

13/126533

Inventors:

Osamu Okamoto - Ibaraki, JP
Yasuhiro Sasaki - Okinawa, JP
Hitomi Watanabe - Ibaraki, JP
Hideki Jona - Ibaraki, JP
Kevin D. Dykstra - West Milford NJ, US

International Classification:

A61K 38/12
C07K 5/00
A61P 3/10

US Classification:

514 69, 530317

Abstract:

The present invention relates to a compound represented by formula (I): wherein Rrepresents a hydrogen atom or the like; Rand Rrepresent a hydrogen atom or the like; Ris a group represented by (II) Rrepresents a phenyl group which may be substituted with a halogen or the like; m is an integer of from 1 to 3; and p is an integer of from 0 to 4; or a pharmaceutically acceptable salt thereof.

US Patent:

62880543, Sep 11, 2001

Filed:

May 24, 1999

Appl. No.:

9/317777

Inventors:

Frank P. Dininno - Old Bridge NJ
Milton L. Hammond - Somerville NJ
Kevin D. Dykstra - West Milford NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D47714
C07D51906
A61K 31428
A61P 3104
C07F 718

US Classification:

51421009

Abstract:

The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: ##STR1## Pharmaceutical compositions and methods of use are also included.

US Patent:

62553003, Jul 3, 2001

Filed:

Dec 7, 1999

Appl. No.:

9/455629

Inventors:

Frank P. Dininno - Old Bridge NJ
Kevin D. Dykstra - West Milford NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D47714
A61K 314195
A61K 314178
A61K 31407
A61P 3104

US Classification:

51421009

Abstract:

The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH. sub. 2 --O-- group. The compounds of the invention are represented by formula I: ##STR1## wherein A represent O, S or --CH. sub. 2 -- attached at position 3, 4 or 6; Q is selected from the group consisting of: ##STR2##. alpha. represents O, S or NR. sup. s ;. beta. ,. delta. ,. gamma. ,. mu. and. sigma. represent CR. sup. t, N or N+R. sup. s, provided that no more than one of. beta. ,. delta. ,. gamma. ,. mu. and. sigma. is N+R. sup. s, balanced by L. sup. - or a carboxylate anion. Salts and hydrates thereof are included. The iodo-substituted phenyl ring is further substituted with various substituent groups including at least one cationic group. Pharmaceutical compositions and methods of treatment are also included.