Kenrick H Kuwahara

US Patent:

8308686, Nov 13, 2012

Filed:

May 28, 2010

Appl. No.:

12/790240

Inventors:

Ellis Meng - Pasadena CA, US
Yu-Chong Tai - Pasadena CA, US
Mark Humayun - Glendale CA, US
Rajat Agrawal - Redlands CA, US
Ronalee Lo - Monterey Park CA, US
Jason Shih - Yorba Linda CA, US
Kenrick Kuwahara - Woodland Hills CA, US
Damien Rodger - Los Angeles CA, US

Assignee:

The University of Southern California - Los Angeles CA

International Classification:

A61F 7/12

US Classification:

604114

Abstract:

Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.

US Patent:

20080039792, Feb 14, 2008

Filed:

Mar 14, 2007

Appl. No.:

11/686310

Inventors:

Ellis Meng - Pasadena CA, US
Yu-Chong Tai - Pasadena CA, US
Mark Humayun - Glendale CA, US
Rajat Agrawal - Redlands CA, US
Ronalee Lo - Monterey Park CA, US
Jason Shih - Yorba Linda CA, US
Kenrick Kuwahara - Woodland Hills CA, US
Damien Rodger - Los Angeles CA, US

International Classification:

A61M 5/00

US Classification:

604114000

Abstract:

An implantable device for delivering a therapeutic agent to a patient is provided. The device includes a reservoir configured to contain a liquid comprising the therapeutic agent. The device further includes a cannula in fluid communication with the reservoir. The cannula has an outlet configured to be in fluid communication with the patient. The device further includes a first electrode and a second electrode, at least one of the first electrode and the second electrode is planar. The device further includes a material in electrical communication with the first and second electrodes. A voltage applied between the first electrode and the second electrode produces gas from the material, the gas forcing the liquid to flow from the reservoir to the outlet.

US Patent:

20100215715, Aug 26, 2010

Filed:

Feb 19, 2010

Appl. No.:

12/709238

Inventors:

Bo Han - Temple City CA, US
Kenrick Kuwahara - Woodland Hills CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 35/12
A61K 35/48
A61P 19/00

US Classification:

424423, 424 937

Abstract:

The present invention discloses methods and compositions comprising a biocompatible gel that is used in tissue repair and regeneration. Once the gel is administered to a tissue site in need of repair or regeneration, the cells migrate from the gel into the tissue and repair or regenerate the tissue.

US Patent:

20110144617, Jun 16, 2011

Filed:

Feb 11, 2011

Appl. No.:

13/026136

Inventors:

Ellis MENG - Pasadena CA, US
Yu-Chong Tai - Pasadena CA, US
Mark S. Humayun - Glendale CA, US
Rajat Agrawal - Redlands CA, US
Ronalee Lo Monterey Park - Monterey Park CA, US
Jason Shih - Yorba Linda CA, US
Kenrick Kuwahara - Woodland Hills CA, US
Damien Rodger - Los Angeles CA, US

Assignee:

The University of Southern California - Los Angeles CA

International Classification:

A61M 5/152
A61M 5/14

US Classification:

604500, 604131

Abstract:

Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, a cannula in fluid communication with the reservoir, and means for forcing fluid from the reservoir into the cannula. Circuitry for controlling the means for forcing fluid from the reservoir into the cannula may be included.

US Patent:

20110144619, Jun 16, 2011

Filed:

Feb 11, 2011

Appl. No.:

13/026121

Inventors:

Ellis MENG - Pasadena CA, US
Yu-Chong Tai - Pasadena CA, US
Mark S. Humayun - Glendale CA, US
Rajat Agrawal - Redlands CA, US
Ronalee Lo - Monterey Park CA, US
Jason Shih - Yorba Linda CA, US
Kenrick Kuwahara - Woodland Hills CA, US
Damien Rodger - Los Angeles CA, US

Assignee:

The University of Southern California - Los Angeles CA

International Classification:

A61M 5/152
A61M 5/14

US Classification:

604506, 604246, 604141

Abstract:

Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included.

US Patent:

20130149351, Jun 13, 2013

Filed:

Dec 7, 2012

Appl. No.:

13/708830

Inventors:

California Institute of Technology - Pasadena CA, US
University of Southern California - Los Angeles CA, US
Paresma Patel - Frederick MD, US
Mark Humayun - Glendale CA, US
Kenrick Kuwahara - Cypress CA, US
Michael Janusz Koss - Pasadena CA, US
Yi Zhang - Cypress CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

A61K 9/00
C12N 5/071
C08G 63/91

US Classification:

424400, 528354, 525 541, 424 783, 435377, 435396, 4284744

Abstract:

The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for growing RPE cells. Additionally, the present invention provides for RGD peptide linked polymer scaffolds for supporting the growth of RPE cells. The present invention provides methods of culturing RPE cells using the scaffolds produced herein. The present invention also provides methods of treating vision loss through the administration of RPE cell attached RGD peptide linked polymer scaffolds produced herein. The present invention further provides kits for treating vision loss.

US Patent:

20130202564, Aug 8, 2013

Filed:

Apr 8, 2011

Appl. No.:

13/640027

Inventors:

Bo Han - Temple City CA, US
Kenrick Kuwahara - Woodland Hills CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

A61K 47/42
A61K 38/54

US Classification:

424 937, 424 942, 424 943, 435174, 435177

Abstract:

This invention provides a composition for controlled-release of polypeptide growth factors useful in tissue repair or engineering. The composition include a polypeptide growth factor covalently cross-linked to a biocompatible substrate by a transgultaminase. The cross-linking tethers the growth factor to a substrate so that it will not diffuse away from the desired site of application. It also concomitantly inactivates the growth factor. Release and reactivation of the growth factor can be achieved by endogenously produced metalloproteinase (MMPs) or exogenously provided proteases such as collagenases. Also provided are scaffolds, transplant devices, methods for using the same and methods for making the same,

US Patent:

20160000602, Jan 7, 2016

Filed:

Sep 15, 2015

Appl. No.:

14/854854

Inventors:

Ellis MENG - Pasadena CA, US
Yu-Chong TAI - Pasadena CA, US
Mark S. HUMAYUN - Glendale CA, US
Rajat AGRAWAL - Redlands CA, US
Ronalee LO - Monterey Park CA, US
Jason SHIH - Yorba Linda CA, US
Kenrick KUWAHARA - Woodland Hills CA, US
Damien ROGER - Los Angeles CA, US

International Classification:

A61F 9/00
A61M 5/168
A61M 5/142

Abstract:

Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. When a predetermined cracking pressure is reached, a valve opens and allows the liquid to flow through the cannula.