Kanji M Meghpara

US Patent:

20060222701, Oct 5, 2006

Filed:

Mar 28, 2006

Appl. No.:

11/391518

Inventors:

Neema Kulkarni - Randolph NJ, US
Kanji Meghpara - Morris Plains NJ, US

International Classification:

A61K 9/48

US Classification:

424451000

Abstract:

In various embodiments of the present invention, a capsule is provided including a hydrophobic inner layer and at least one hydrophilic outer layer. The hydrophobic layer may include a hydrophilic component such as an active pharmaceutical ingredient (API) which may be fully encapsulated, partially encapsulated or part of an adsorption complex. Such capsules experience no or minimal cracking or breaking in the outer layer.

US Patent:

20070134493, Jun 14, 2007

Filed:

Dec 8, 2005

Appl. No.:

11/296989

Inventors:

Kanji Meghpara - Morris Plains NJ, US

International Classification:

B32B 9/00

US Classification:

428402200

Abstract:

Several embodiments of the present invention provide a capsule including a hydrophobic inner core layer and at least one hydrophilic outer layer. The outer layer may be seamless and may include at least one hygroscopic polyol and at least one polyol with a low hygroscopicity. The at least one outer layer may include at least one film or gel forming agent. Such capsules are stable and experience minimal or no degradation under accelerated stability conditions.

US Patent:

20140065213, Mar 6, 2014

Filed:

May 4, 2012

Appl. No.:

14/115896

Inventors:

Dongzhou Liu - Parsippany NJ, US
Kanji Meghpara - Parsippany NJ, US

Assignee:

GlaxoSmithKline, LLC - Philadelphia

International Classification:

A61K 9/24
A61K 31/167

US Classification:

424472, 514630

Abstract:

The present invention is directed to twice daily sustained release pharmaceutical composition of paracetamol having an immediate release phase of paracetamol and a sustained release phase of paracetamol, said composition having unique and advantageous pharmacokinetic properties and a pharmaceutical composition comprising only a sustained release phase of paracetamol having unique and advantageous pharmacokinetic properties.

US Patent:

20210137827, May 13, 2021

Filed:

Jan 19, 2021

Appl. No.:

17/151782

Inventors:

- Bridgewater NJ, US
Dipen Desai - Whippany NJ, US
Wantanee Phuapradit - Montville NJ, US
Jaydeep Vaghashiya - Franklin park NJ, US
Kanji Meghpara - Morris Plains NJ, US

Assignee:

KASHIV SPECIALTY PHARMACEUTICALS, LLC - Bridgewater NJ

International Classification:

A61K 9/00
A61K 47/32
A61K 47/12
A61K 47/02

Abstract:

Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen, adequate membrane permeability that provides for fast generation of COfrom a gas-generating agent(s), and adequate membrane elasticity that provides for rapid expansion of the membrane. The hydrated core, especially the polyethylene oxide in the push layer, and the permeable elastic membrane with an orifice (1) provide extended release of the active pharmaceutical agent, and (2) maintain the dosage form at a size suitable for gastric retention. The self-regulating composition collapses, or breaks into pieces, after releasing at least about 80% of the drug from the composition.

US Patent:

20210052487, Feb 25, 2021

Filed:

Oct 29, 2020

Appl. No.:

17/083766

Inventors:

- Bridgewater NJ, US
Dipen Desai - Whippany NJ, US
Wantanee Phuapradit - Montville NJ, US
Jaydeep Vaghashiya - Franklin park NJ, US
Kanji Meghpara - Morris Plains NJ, US

Assignee:

KASHIV SPECIALTY PHARMACEUTICALS, LLC - Bridgewater NJ

International Classification:

A61K 9/00
A61K 47/02
A61K 47/12
A61K 47/32

Abstract:

Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen, adequate membrane permeability that provides for fast generation of COfrom a gas-generating agent(s), and adequate membrane elasticity that provides for rapid expansion of the membrane. The hydrated core, especially the polyethylene oxide in the push layer, and the permeable elastic membrane with an orifice (1) provide extended release of the active pharmaceutical agent, and (2) maintain the dosage form at a size suitable for gastric retention. The self-regulating composition collapses, or breaks into pieces, after releasing at least about 80% of the drug from the composition.

US Patent:

20200330368, Oct 22, 2020

Filed:

Jun 29, 2020

Appl. No.:

16/914540

Inventors:

- Bridgewater NJ, US
Dipen Desai - Whippany NJ, US
Wantanee Phuapradit - Montville NJ, US
Jaydeep Vaghashiya - Woodbridge NJ, US
Kanji Meghpara - Morris Plains NJ, US

Assignee:

KASHIV BIOSCIENCES, LLC - Bridgewater NJ

International Classification:

A61K 9/00
A61K 47/02
A61K 47/12
A61K 47/32

Abstract:

Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen, adequate membrane permeability that provides for fast generation of COfrom a gas-generating agent(s), and adequate membrane elasticity that provides for rapid expansion of the membrane. The hydrated core, especially the polyethylene oxide in the push layer, and the permeable elastic membrane with an orifice (1) provide extended release of the active pharmaceutical agent, and (2) maintain the dosage form at a size suitable for gastric retention. The self-regulating composition collapses, or breaks into pieces, after releasing at least about 80% of the drug from the composition.

US Patent:

20200179267, Jun 11, 2020

Filed:

Jan 31, 2020

Appl. No.:

16/778439

Inventors:

- Bridgewater NJ, US
Wantanee Phuapradit - Montville NJ, US
Dipen Desai - Whippany NJ, US
Jaydeep Vaghashiya - Woodbridge NJ, US
Kanji Meghpara - Morris Plains NJ, US

Assignee:

KASHIV BIOSCIENCES, LLC - Bridgewater NJ

International Classification:

A61K 9/00
A61K 47/02
A61K 47/12
A61K 47/32

Abstract:

Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as, optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen, adequate membrane permeability that provides for fast generation of COfrom a gas-generating agent(s), and adequate membrane elasticity that provides for rapid expansion of the membrane. The hydrated core, especially the polyethylene oxide in the push layer, and the permeable elastic membrane with an orifice (1) provide extended release of the active pharmaceutical agent, and (2) maintain the dosage form at a size suitable for gastric retention. The self-regulating composition collapses, or breaks into pieces, after releasing at least about 80% of the drug from the composition.

US Patent:

20200155446, May 21, 2020

Filed:

Jun 27, 2019

Appl. No.:

16/634792

Inventors:

- Bridgewater NJ, US
Wantanee Phuapradit - Montville NJ, US
Dipen Desai - Whippany NJ, US
Jaydeep Vaghashiya - Woodbridge NJ, US
Kanji Meghpara - Morris Plains NJ, US

Assignee:

KASHIV BIOSCIENCES, LLC - Bridgewater NJ

International Classification:

A61K 9/00
A61K 47/32
A61K 47/12
A61K 47/02

Abstract:

Self-regulating, osmotic, floating gastroretentive compositions that provide extended release, delayed release, and/or delayed extended release of active pharmaceutical agents, as well as. optionally, immediate release of the same or a different active pharmaceutical agent, are provided here. The gastroretentive compositions of the disclosure comprise a swellable, extended release, multilayer core comprising a push layer and a pull layer; a water-insoluble permeable elastic membrane surrounding the multilayer core; and an orifice (e.g., a laser-drilled orifice, a manually drilled orifice) on the pull-layer side of the dosage form. The gastric retention of the composition is controlled by rapid floating of the composition and expansion of the membrane. The rapid swelling of the composition to a size greater than the size of the pyloric sphincter is due to the presence of an osmogen. adequate membrane permeability that provides for fast generation of COfrom a gas-generating agent(s), and adequate membrane elasticity that provides for rapid expansion of the membrane. The hydrated core, especially the polyethylene oxide in the push layer, and the permeable elastic membrane with an orifice (1) provide extended release of the active pharmaceutical agent, and (2) maintain the dosage form at a size suitable for gastric retention. The self-regulating composition collapses, or breaks into pieces, after releasing at least about 80% of the drug from the composition.