Juan Cui

US Patent:

20120053080, Mar 1, 2012

Filed:

Feb 19, 2010

Appl. No.:

13/255527

Inventors:

Juan Cui - Athens GA, US
J. David Puett - Athens GA, US
Seulgi Hong - Duluth GA, US
Ying Xu - Bogart GA, US

International Classification:

C40B 30/04
C12Q 1/37
C07K 14/78
C12N 9/64
C12N 9/90
C12N 9/20
G01N 33/574
C07K 14/47

US Classification:

506 9, 436501, 435 23, 530395, 435226, 435233, 530350, 435198, 530356, 435 74

Abstract:

Methods for detecting cancer as well as methods of diagnosis of cancer by detecting proteins secreted into biological fluids are disclosed The invention was first applied to detecting proteins secreted into serum and urine However, it is understood that the methods have broader application to developing tools and systems for detecting proteins secreted into other biological fluids such as, but not limited to, saliva, spinal fluid, seminal fluid, vaginal fluid, and ocular fluid Reliable detection of proteins secreted into biological fluids provided by embodiments of the methods will enable more timely and accurate detection and diagnosis of cancer.

US Patent:

20110224913, Sep 15, 2011

Filed:

Aug 10, 2009

Appl. No.:

13/055251

Inventors:

Juan Cui - Athens GA, US
David Puett - Athens GA, US
Ying Xu - Bogart GA, US

International Classification:

G06F 19/00

US Classification:

702 19

Abstract:

The present invention is directed to methods and systems for predicting protein secretion into bodily fluids. In an embodiment, a method uses a feature set comprising secretory properties of collected proteins to train a classifier, based on the feature set, to recognize protein features corresponding to proteins that are likely to be secreted into a biological fluid. Another method determines, using a trained classifier and identified features of a received protein sequence, the probability of the protein sequence being secreted into a biological fluid. In an embodiment, a system predicts the secretion of proteins into a biological fluid. The system comprises components configured to construct a protein feature set comprising properties of collected proteins, train a classifier to predict features of a protein that is likely to be secreted into the biological fluid, receive a protein sequence, and identify the received protein sequence as a secretory protein.