Joseph S Grippo

US Patent:

6528543, Mar 4, 2003

Filed:

Mar 21, 2000

Appl. No.:

09/532506

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Antonio Focella - Wayne NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - North Caldwell NJ
Robert Francis Kester - Hackensack NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

A61K 3117

US Classification:

514594, 514522, 514530, 514542, 514595, 558413, 558417, 560 9, 560 13, 564 47, 564 56

Abstract:

Glucokinase activating compounds of the formula wherein R and R are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R and R are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

US Patent:

6610846, Aug 26, 2003

Filed:

Sep 28, 2000

Appl. No.:

09/675781

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - Houston TX
Robert Francis Kester - Verona NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D23724

US Classification:

544182, 544211, 544224, 544238, 544329, 544336

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

6951945, Oct 4, 2005

Filed:

Jul 9, 2003

Appl. No.:

10/616359

Inventors:

Fred Thomas Bizzarro - Colonia NJ, US
Wendy Lea Corbett - Randolph NJ, US
Joseph Francis Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George William Holland - Houston TX, US
Robert Francis Kester - Verona NJ, US
Paige Erin Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D285/06
C07D285/12
C07D277/04
C07D275/02

US Classification:

548127, 548128, 548134, 548139, 548195, 548214

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

7223868, May 29, 2007

Filed:

Apr 4, 2005

Appl. No.:

11/098717

Inventors:

Fred Thomas Bizzarro - Colonia NJ, US
Wendy Lea Corbett - Randolph NJ, US
Joseph Francis Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George William Holland - Houston TX, US
Robert Francis Kester - Verona NJ, US
Paige Erin Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 213/75
C07D 213/84

US Classification:

546289, 546297, 546309, 546310

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

20070203207, Aug 30, 2007

Filed:

Apr 23, 2007

Appl. No.:

11/789105

Inventors:

Fred Bizzarro - Colonia NJ, US
Wendy Corbett - Randolph NJ, US
Joseph Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George Holland - Houston TX, US
Robert Kester - Verona NJ, US
Paige Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

International Classification:

A61K 31/425
C07C 211/00
C07C 211/01
C07C 311/00
C07D 277/00

US Classification:

514365000, 548199000, 562837000, 564001000, 564366000

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

54280710, Jun 27, 1995

Filed:

Feb 24, 1994

Appl. No.:

8/201493

Inventors:

Werner Bollag - Basel, CH
Joseph F. Grippo - Basking Ridge NJ
Arthur Levin - Glen Ridge NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 3120

US Classification:

514559

Abstract:

The compound 9-cis-retinoic acid, its pharmaceutically acceptable salts or its pharmaceutically acceptable esters can be used in the treatment of precancerous or premalignant epithelial lesions as well as in the treatment of malignant tumors of an epithelial nature.

US Patent:

63200503, Nov 20, 2001

Filed:

Mar 15, 2000

Appl. No.:

9/526143

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - North Caldwell NJ
Robert Francis Kester - Hackensack NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D27738
C07D21326
C07D23942

US Classification:

544332

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.