Jose R Pardinas

US Patent:

6413720, Jul 2, 2002

Filed:

Jan 11, 1999

Appl. No.:

09/228455

Inventors:

Jose R. Pardinas - San Diego CA
Kyle W. H. Chan - San Diego CA

Assignee:

Signal Pharmaceuticals, Inc. - San Diego CA

International Classification:

C12Q 168

US Classification:

435 6, 536 254, 536 231

Abstract:

Methods are provided for the isolation of newly synthesized mRNA. Such methods involve the incorporation of biotinylated rNTP analogues into cellular mRNA, and separating biotinylated mRNA from unlabeled RNA. The methods provided herein may be used, for example, for gene discovery, drug screens and studies of the regulation of gene expression.

US Patent:

6960438, Nov 1, 2005

Filed:

May 23, 2002

Appl. No.:

10/154517

Inventors:

Jose R. Pardinas - San Diego CA, US
Kyle W. H. Chan - San Diego CA, US

Assignee:

Signal Pharmaceuticals, LLC - San Diego CA

International Classification:

C07H021/04
C12Q001/68

US Classification:

435 6, 435 911, 536 231, 536 243

Abstract:

Methods are provided for the isolation of newly synthesized mRNA. Such methods involve the incorporation of biotinylated rNTP analogues into cellular mRNA, and separating biotinylated mRNA from unlabeled RNA. The methods provided herein may be used, for example, for gene discovery, drug screens and studies of the regulation of gene expression.

US Patent:

20030054332, Mar 20, 2003

Filed:

May 10, 2001

Appl. No.:

09/853544

Inventors:

Miguel Barbosa - Claremont CA, US
Helen Brady - San Diego CA, US
Kyle Chan - San Diego CA, US
Jose Pardinas - Bothell WA, US

International Classification:

C12Q001/00
C12Q001/68
C07H021/04
C12N005/06

US Classification:

435/004000, 435/006000, 435/325000, 536/023500

Abstract:

Methods are provided for evaluating estrogenic and antiestrogenic effects of candidate therapeutic agents. Such methods are generally based on assays to detect modulation of estrogen-regulated marker expression in one or more specific cell types. Agents identified using such methods may be used, for example, in the prevention and treatmnt of diseases such as osteoporosis, cardiovascular disease and cancer. In addition, the gene discovery approaches discussed have identified a unique gene profile for estrogen regulation in vascular endothelial cells. This gene profile will allow characterization of the effects of potential SERMs in the cardiovascular system. This gene profile and the assays established with these genes will enable more extensive evaluation of tissue specific properties of SERM compounds and provide a better understanding of cardiovascular effects of SERMs.

US Patent:

20110091971, Apr 21, 2011

Filed:

Jun 29, 2009

Appl. No.:

12/493741

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Gopalan Raghunathan - San Diego CA, US
Michael Joseph Hunter - San Diego CA, US
Jose Pardinas - San Diego CA, US
Judith Ann Connor - San Diego CA, US
Ronald Vernon Swanson - San Diego CA, US
Ellen Chi - San Diego CA, US

International Classification:

C12N 5/0735
C12N 5/071

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20110224086, Sep 15, 2011

Filed:

Mar 9, 2010

Appl. No.:

12/720060

Inventors:

Jose Pardinas - San Diego CA, US
Shanrong Zhao - San Diego CA, US

International Classification:

C40B 20/00
C40B 50/04
C40B 30/00

US Classification:

506 2, 506 25, 506 7

Abstract:

The present invention relates to methods and algorithms for identifying, synthesizing and co-assembling combinatorial libraries of polynucleotide variants.

US Patent:

20120093833, Apr 19, 2012

Filed:

Oct 10, 2011

Appl. No.:

13/269976

Inventors:

Juan Carlos Almagro - Radnor PA, US
William DuBell - Radnor PA, US
Johan Fransson - San Diego CA, US
Jose Pardinas - Radnor PA, US

International Classification:

C07K 16/24
C12N 15/13
C12N 5/10
C12P 21/02
A61P 19/02
A61P 17/06
A61P 11/00
A61P 11/06
A61P 25/00
A61P 29/00
A61P 19/08
A61P 9/10
A61P 13/12
A61P 35/00
A61K 39/395

US Classification:

4241581, 5303892, 5303873, 536 2353, 435335, 435 696

Abstract:

Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.

US Patent:

60459980, Apr 4, 2000

Filed:

Apr 2, 1997

Appl. No.:

8/832021

Inventors:

Nicholas Combates - New Brunswick NJ
Jose R. Pardinas - Staten Island NY
Satish Parimoo - Bridgewater NJ
Stephen M. Prouty - Doylestown PA
Kurt S. Stenn - Princeton NJ

Assignee:

Johnson & Johnson Consumer Products, Inc. - Skillman NJ

International Classification:

C12Q 168
C12P 1934

US Classification:

435 6

Abstract:

The method of this invention relates to the use of improved anchor primers and a novel purification process to increase the efficiency and accuracy of the differential display technique.

US Patent:

20190092856, Mar 28, 2019

Filed:

Dec 10, 2018

Appl. No.:

16/214891

Inventors:

- Horsham PA, US
William DuBell - Jamison PA, US
Johan Fransson - Toronto, CA
Jose Pardinas - San Diego CA, US
Gopalan Raghunathan - San Diego CA, US

International Classification:

C07K 16/24
C12N 15/09
C07H 21/00
A61K 39/00

Abstract:

Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.