John D Westley

US Patent:

41705955, Oct 9, 1979

Filed:

Apr 20, 1978

Appl. No.:

5/898053

Inventors:

John Westley - Clifton NJ
Chao-Min Liu - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D20938
C07D40708

US Classification:

260325R

Abstract:

The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.

US Patent:

40768023, Feb 28, 1978

Filed:

Mar 30, 1977

Appl. No.:

5/782680

Inventors:

John Westley - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 3574

US Classification:

424122

Abstract:

A new antibiotic substance X-4357B is obtained by culturing a strain of Streptomyces and recovering said substance from the fermentation mixture. The new substance possesses fungicidal, larvicidal and cytotoxic activities.

US Patent:

41682726, Sep 18, 1979

Filed:

Jun 27, 1977

Appl. No.:

5/810123

Inventors:

John Westley - Mountain Lakes NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D30906

US Classification:

2603457R

Abstract:

Homologs of antibiotic Lasalocid A and their pharmaceutically acceptable salts are produced by a known species of Streptomyces. The homologs exhibit coccidiostatic and antibacterial activity and thus are useful as coccidiostats and antibacterial agents.

US Patent:

45379564, Aug 27, 1985

Filed:

Nov 23, 1983

Appl. No.:

6/554506

Inventors:

Chao-Min Liu - Cedar Grove NJ
John Westley - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07H 300

US Classification:

536 11

Abstract:

There is presented antibiotic compounds designated as Antibiotics X-14889 A, C and D of the formulas ##STR1## wherein (for X-14889A) R. sub. 1 is methyl, R. sub. 2 is methyl, R. sub. 3 is hydrogen, R. sub. 4 is methyl and R. sub. 5 is hydrogen or (for X-14889C) R. sub. 1 is hydrogen, R. sub. 2 is methyl, R. sub. 3 is hydrogen, R. sub. 4 is methyl and R. sub. 5 is CO. sub. 2 H or ##STR2## and the pharmaceutically acceptable salts thereof. The compounds exhibit antimicrobial activity and one of the compounds X-14889C also exhibits activity against Treponema hyodysenteriae (in vitro), Plasmodium berghei and as food efficiency enhancers in ruminants. Also presented is a process to produce the above compounds and another known component Antibiotic X-14889B.

US Patent:

39503208, Apr 13, 1976

Filed:

Jun 26, 1974

Appl. No.:

5/483259

Inventors:

Arthur Stempel - Teaneck NJ
John Westley - Mountain Lakes NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A23K 117
A61K 2100
C07D 7100

US Classification:

260152

Abstract:

Derivatives of antibiotic X-537A of the formula Wherein R. sub. 1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, and phenyl substituted by a member of the group consisting of halogen, nitro, and lower alkyl; R. sub. 2 is selected from the group consisting of hydrogen, lower alkyl, lower alkanoyl, ##SPC1## benzoyl, and benzoyl substituted by a member of the group consisting of halogen, nitro and lower alkyl; R. sub. 5 is selected from the group consisting of phenylazo and phenylazo substituted by a member of the group consisting of halogen, nitro, lower alkyl and lower alkoxy; and R. sub. 4 is selected from the group consisting of --OH, =O, and =N--OH and the pharmaceutically acceptable alkali metal, alkaline earth metal and ammonium salts thereof, together with methods for their preparation are disclosed. These derivatives are useful as coccidiostatic agents and antibacterial agents.

US Patent:

43529348, Oct 5, 1982

Filed:

Oct 14, 1981

Appl. No.:

6/311132

Inventors:

Chao-Min Liu - Cedar Grove NJ
Homer D. Tresner - LaFarge WI
John Westley - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D41302

US Classification:

548217

Abstract:

There is presented an antibiotic compound of the formula ##STR1## and the pharmaceutically acceptable salts and esters thereof. The compound exhibits activity as an anti-swine dysentery agent and an antimicrobial agent. Also presented is a fermentation process to produce the compound of formula I.

US Patent:

41295803, Dec 12, 1978

Filed:

Nov 14, 1977

Appl. No.:

5/851317

Inventors:

John Westley - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D30722
C07C 8526

US Classification:

2603477

Abstract:

Racemic modifications of optically active primary or tertiary amines are treated with lasalocid to form diastereomeric salts. The so-formed diastereomeric salts are separated and, subsequently, can be chemically decomposed to give the desired enantiomers of the amine. The resolving agent, lasalocid, is recovered in this process by precipitation or evaporation from organic solvents.

US Patent:

43682650, Jan 11, 1983

Filed:

Feb 23, 1981

Appl. No.:

6/237544

Inventors:

Chao-Min Liu - Cedar Grove NJ
Barbara Prosser - Bloomfield NJ
John Westley - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C12P 1960
C12P 1718

US Classification:

435 75

Abstract:

Antibiotic X-14868A having the following chemical structure ##STR1## and the pharmaceutically acceptable salts thereof is presented. Also presented is a fermentative method of producing the above antibiotic. Antibiotic X-14868A exhibits anticoccidiostatic activity.