John S Tokarski

US Patent:

6653304, Nov 25, 2003

Filed:

Feb 8, 2001

Appl. No.:

09/779109

Inventors:

Katerina Leftheris - Skillman NJ
Hong Wu - Lawrenceville NJ
Stephen Wrobleski - Whitehouse Station NJ
Ping Chen - Belle Mead NJ
John Hynes - Washington Crossing PA
John Tokarski - Princeton NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D40312

US Classification:

5142328, 514292, 544126, 546 81

Abstract:

Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R -R are as defined in the specification, wherein R with R may form a ring, and/or two R groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R forming a ring with R.

US Patent:

6795776, Sep 21, 2004

Filed:

Oct 13, 2000

Appl. No.:

09/687609

Inventors:

Roberto Weinmann - Lawrenceville NJ
Howard M. Einspahr - Lawrenceville NJ
Stanley R. Krystek - Ringoes NJ
John S. Sack - Lawrenceville NJ
Mark E. Salvati - Lawrenceville NJ
John S. Tokarski - Princeton NJ
Ricardo M. Attar - Lawrenceville NJ
Chihuei Wang - Plainsboro NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

G01N 3100

US Classification:

702 27, 530350, 530399, 552621

Abstract:

The first crystal structure of the androgen receptor ligand binding domain has been determined to 2. 0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonists and selective androgen receptors modulators (SARMs) of the androgen receptor.

US Patent:

7084160, Aug 1, 2006

Filed:

Jun 18, 2003

Appl. No.:

10/464139

Inventors:

Robert M. Borzilleri - New Hope PA, US
Rajeev S. Bhide - Princeton Jct NJ, US
John S. Tokarski - Princeton NJ, US
Peter Zheng - Lawrenceville NJ, US
Ligang Qian - Hopewell NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/44
C07D 417/12

US Classification:

514342, 5462681, 5462697, 5462707

Abstract:

The present invention provides compounds of formula IThe formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

US Patent:

7141571, Nov 28, 2006

Filed:

Dec 22, 2004

Appl. No.:

11/019901

Inventors:

Brian E. Fink - Princeton Junction NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Gregory D. Vite - Titusville NJ, US
Ping Chen - Belle Mead NJ, US
Harold Mastalerz - Guilford CT, US
Derek J. Norris - Pennington NJ, US
John S. Tokarski - Princeton NJ, US
Yufen Zhao - Pennington NJ, US
Wen-Ching Han - Newton PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514243, 544183

Abstract:

The present invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

US Patent:

7225083, May 29, 2007

Filed:

Jun 28, 2004

Appl. No.:

10/878851

Inventors:

Roberto Weinmann - Lawrenceville NJ, US
Howard M. Einspahr - Lawrenceville NJ, US
Stanley R. Krystek - Ringoes NJ, US
John S. Sack - Lawrenceville NJ, US
Mark E. Salvati - Lawrenceville NJ, US
John S. Tokarski - Princeton NJ, US
Ricardo M. Attar - Lawrenceville NJ, US
Chihuei Wang - Plainsboro NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

G01N 31/00
G06F 19/00
C07K 1/00
C07J 1/00
A61K 38/22

US Classification:

702 27, 530350, 530399, 552621

Abstract:

The first crystal structure of the androgen receptor ligand binding domain has been determined to 2. 0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonists and selective androgen receptors modulators (SARMs) of the androgen receptor.

US Patent:

7297695, Nov 20, 2007

Filed:

Jun 26, 2006

Appl. No.:

11/426479

Inventors:

Brian E. Fink - Princeton Junction NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Gregory D. Vite - Titusville NJ, US
Ping Chen - Belle Mead NJ, US
Harold Mastalerz - Guilford CT, US
Derek J. Norris - Pennington NJ, US
John S. Tokarski - Princeton NJ, US
Yufen Zhao - Pennington NJ, US
Wen-Ching Han - Newtown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
C07D 401/06
C07D 401/14
A61K 31/53
A61P 35/00

US Classification:

514243, 544183

Abstract:

The present invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

US Patent:

7378426, May 27, 2008

Filed:

Feb 25, 2005

Appl. No.:

11/066407

Inventors:

Ashvinikumar V. Gavai - Princeton Junction NJ, US
Derek J. Norris - Pennington NJ, US
Wen-Ching Han - Newtown PA, US
Gregory D. Vite - Titusville NJ, US
Brian E. Fink - West Windsor NJ, US
John S. Tokarski - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A01N 43/42
A61K 31/44
C07D 487/00
C07D 491/00
C07D 513/00

US Classification:

514291, 540476

Abstract:

Disclosed are fused heterotricyclic compounds of the following formula I,.

US Patent:

7417040, Aug 26, 2008

Filed:

Feb 25, 2005

Appl. No.:

11/066373

Inventors:

Brian E. Fink - West Windsor NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Gregory D. Vite - Titusville NJ, US
Wen-Ching Han - Newtown PA, US
Raj N. Misra - Hopewell NJ, US
Derek J. Norris - Pennington NJ, US
John S. Tokarski - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/33
C07D 225/04
C07D 267/22
C07D 281/18
C07D 291/00
C07D 337/16
A01N 43/00

US Classification:

514183, 540466

Abstract:

Disclosed are fused tricyclic compounds of the following formula I,.