John Andrew Mcgowen

US Patent:

6391937, May 21, 2002

Filed:

Jun 25, 1999

Appl. No.:

09/344217

Inventors:

Allyson Beuhler - Downers Grove IL
John McGowen - Crystal Lake IL

Assignee:

Motorola, Inc. - Northfield IL

International Classification:

C03F 7027

US Classification:

522152, 522117, 522121, 526304, 5263072, 5263076, 5263077, 4284744, 4302811, 4302831, 4302871, 435 6, 435 71, 4352872

Abstract:

The present invention provides polyacrylamide hydrogels (especially polyacrylamide hydrogel arrays) made from prepolymers and polyacrylamide reactive polymers, as well as methods and compositions for preparing the polyacrylamide hydrogels or hydrogel arrays. The method advantageously provides greater control of polyacrylamide pore size and crosslink density, allowing, for instance, preparation of a polyacrylamide hydrogel appropriate for use with DNA. Furthermore, the methods and compositions can be employed in commercial processes.

US Patent:

6686161, Feb 3, 2004

Filed:

Oct 11, 2001

Appl. No.:

09/976986

Inventors:

Travis Johnson - Chandler AZ
John McGowen - Crystal Lake IL
Allyson Beuhler - Downers Grove IL
Charles Kimball Brush - Whitefish Bay WI
Robert Emil Lajos - Crystal Lake IL

Assignee:

Amersham Biosciences AB - Uppsala

International Classification:

C08J 328

US Classification:

435 6, 435181, 436532, 436531, 522114, 522116, 522117, 522120, 522121, 522152, 522153, 522148, 527200, 527201

Abstract:

The present invention provides solid supports (e. g. , glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.

US Patent:

20020115740, Aug 22, 2002

Filed:

Apr 23, 2002

Appl. No.:

10/131426

Inventors:

Allyson Beuhler - Downers Grove IL, US
John McGowen - Crystal Lake IL, US

Assignee:

Motorola, Inc.

International Classification:

C08J003/28

US Classification:

522/152000

Abstract:

Reactive prepolymers incorporating [2+2] photoreactive sites are synthesized. Upon exposure to UV light, these prepolymers undergo [2+2] cycloaddition to crosslink. When crosslinked, the reactive prepolymers form a hydrogel. Selective hydrogel formation is provided through selective exposure of the reactive prepolymer to UV light. Supports and other molecules may be attached or incorporated into the hydrogel through [2+2] cycloaddition with uncrosslinked [2+2] photoreactive sites present in the hydrogel.

US Patent:

6372813, Apr 16, 2002

Filed:

Jun 25, 1999

Appl. No.:

09/344620

Inventors:

Travis Johnson - Chandler AZ
John McGowen - Crystal Lake IL
Allyson Beuhler - Downers Grove IL
Charles Kimball Brush - Whitefish Bay WI
Robert Emil Lajos - Crystal Lake IL

Assignee:

Motorola - Schaumburg IL

International Classification:

C08J 328

US Classification:

522114, 522116, 522117, 522120, 522149, 522152, 5262381, 527200, 527201, 527207, 527300, 527309, 527314, 527315, 435174, 435177, 435180, 435181

Abstract:

The present invention provides solid supports (e. g. , glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.