Cheng Liu - Richmond CA, US John Kunich - Emeryville CA, US Michael Kavanaugh - Emeryville CA, US
Assignee:
Novartis AG - Basel Xoma Technology Ltd. - Hamilton
International Classification:
G01N 33/53
US Classification:
435 792
Abstract:
Soluble human M-CSF receptor is provided, along with pharmaceutical compositions containing such receptor, kits containing a pharmaceutical composition, and methods of diagnosing and treating diseases and disorders associated with M-CSF such as bone loss in a subject afflicted with an osteolytic disease.
- Basel, CH John Kunich - Orinda CA, US William Michael Kavanaugh - Orinda CA, US
Assignee:
XOMA TECHNOLOGY LTD. - Berkeley CA NOVARTIS AG - Basel
International Classification:
G01N 33/68
US Classification:
435 772, 435 792
Abstract:
Soluble human M-CSF receptor is provided, along with pharmaceutical compositions containing such receptor, kits containing a pharmaceutical composition, and methods of diagnosing and treating diseases and disorders associated with M-CSF such as bone loss in a subject afflicted with an osteolytic disease.
John Kunich - San Leandro CA, US Cheng Liu - Richmond CA, US
International Classification:
G01N 33/574 G01N 33/566
US Classification:
435 723, 435 72
Abstract:
Methods for detecting antibody dependent cellular cytotoxicity (ADCC) are described herein. The methods are label-free, and can be performed in real time on adherent cells. The methods can include, for example, (a) monitoring the impedance between electrodes on a non-conducting substrate that supports the growth of target cells in an assay medium; and (b) adding effector cells and an antibody that binds to the target cells to the assay medium; wherein any decrease in the impedance between the electrodes on the substrate following addition of the effector cells and the antibody is indicative of ADCC function having been effected in the assay medium.
John Kunich (1967-1971), Thomas Dunn (1966-1970), Ray Toren (1953-1957), Jerome Domrese (1974-1978), Lawrence Lashin (1959-1963), Peter Mikuzis (1959-1963)