Jinzhao Hou

US Patent:

20130209396, Aug 15, 2013

Filed:

Jul 29, 2011

Appl. No.:

13/812582

Inventors:

Thomas M. Barnes - Brookline MA, US
Jinzhao Hou - Belmont MA, US
Bracken M. King - Boston MA, US

Assignee:

ELEVEN BIOTHERAPEUTICS, INC. - Cambridge MA

International Classification:

C07K 14/545

US Classification:

424 852, 530324, 530351, 536 235, 4353201, 43525233, 435 6952

Abstract:

Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1 RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.

US Patent:

57102660, Jan 20, 1998

Filed:

Jan 5, 1997

Appl. No.:

8/781890

Inventors:

Steven L. McKnight - South San Francisco CA
Jinzhao Hou - South San Francisco CA

Assignee:

Tularik Inc. - South San Francisco CA

International Classification:

C12N 1512
C07K 1447

US Classification:

536 235

Abstract:

The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by an interleukin 4 signal transducer and activator of transcription, IL-4 Stat. IL-4 Stat peptides and IL-4 receptor peptides and nucleic acids encoding such peptides find therapeutic uses. The subject compositions include IL-4 Stat and IL-4 receptor proteins, portions thereof, nucleic acids encoding them, and specific antibodies. The disclosed pharmaceutical screening methods are particularly suited to high-throughput screening where one or more steps are performed by a computer controlled electromechanical robot comprising an axial rotatable arm.

US Patent:

55918255, Jan 7, 1997

Filed:

Jul 15, 1994

Appl. No.:

8/276099

Inventors:

Steven L. McKnight - South San Francisco CA
Jinzhao Hou - South San Francisco CA

Assignee:

Tularik, Inc. - So. San Francisco CA

International Classification:

C12N 1512
C07K 1447

US Classification:

530350

Abstract:

The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by an interleukin 4 signal transducer and activator of transcription, IL-4 Stat. IL-4 Stat peptides and IL-4 receptor peptides and nucleic acids encoding such peptides find therapeutic uses. The subject compositions include IL-4 Stat and IL-4 receptor proteins, portions thereof, nucleic acids encoding them, and specific antibodies. The disclosed pharmaceutical screening methods are particularly suited to high-throughput screening where one or more steps are performed by a computer controlled electromechanical robot comprising an axial rotatable arm.

US Patent:

20220339270, Oct 27, 2022

Filed:

Apr 29, 2020

Appl. No.:

17/607141

Inventors:

- Cambridge MA, US
Todd Carter - Cambridge MA, US
Jinzhao Hou - Cambridge MA, US
Yanqun Shu - Cambridge MA, US
Giridhar Murlidharan - Malden MA, US
Martin Goulet - Weston MA, US
Dinah Wen-Yee Sah - Hopkinton MA, US
Steven Paul - Cambridge MA, US
Xin Wang - Arlington MA, US
Hiu Yan Chung - Cambridge MA, US

Assignee:

Voyager Therapeutics, Inc. - Cambridge MA

International Classification:

A61K 39/00
A61P 25/28
C12N 7/00
C12N 15/86

Abstract:

The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

US Patent:

20230131352, Apr 27, 2023

Filed:

Mar 31, 2021

Appl. No.:

17/915393

Inventors:

- Cambridge MA, US
Jinzhao HOU - Lexington MA, US
Wei WANG - Arlington MA, US
Matthew CHILD - Ashland MA, US

International Classification:

C12N 15/86
C12N 15/10

Abstract:

The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.

US Patent:

20230044444, Feb 9, 2023

Filed:

Sep 13, 2022

Appl. No.:

17/931725

Inventors:

- Cambridge MA, US
- Paris, FR
- Strasbourg, FR
Jinzhao Hou - Lexington MA, US
Hélène Puccio - Illkirch, FR

International Classification:

C12N 15/86
A61P 25/00
A61K 48/00
C07K 14/47
C12N 7/00

Abstract:

Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.

US Patent:

20210395776, Dec 23, 2021

Filed:

Sep 27, 2019

Appl. No.:

17/279878

Inventors:

- Cambridge MA, US
Jinzhao HOU - Cambridge MA, US
Hongxing WANG - Cambridge MA, US
Yanqun SHU - Cambridge MA, US
Martin GOULET - Cambridge MA, US
Dinah Wen-Yee SAH - Cambridge MA, US

International Classification:

C12N 15/86
A61K 47/02
A61K 47/10
A61K 48/00
C07K 14/47

Abstract:

The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of frataxin (FXN), whether in vitro and/or in vivo including, but not limited to, the exploitation of engineered promoters. Such compositions include delivery via administration of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Friedreich's ataxia or another neuromuscular or neurological condition resulting from a deficiency in the quantity and/or function of frataxin or associated with decreased expression or protein levels of frataxin.

US Patent:

20210380969, Dec 9, 2021

Filed:

Oct 2, 2019

Appl. No.:

17/282479

Inventors:

- Cambridge MA, US
Jinzhao Hou - Lexington MA, US
Wei Wang - Arlington MA, US
Kei Adachi - Portland OR, US

International Classification:

C12N 15/10
C07K 14/005

Abstract:

The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.