Jeremy Patrick Sauer

US Patent:

20180200386, Jul 19, 2018

Filed:

Mar 21, 2017

Appl. No.:

15/464748

Inventors:

- New York NY, US
- Troy NY, US
Jonathan S. Dordick - Schenectady NY, US
Jeremy Sauer - Princeton NJ, US

International Classification:

A61K 48/00
G01N 33/68
A61K 47/54
A61K 9/51
A61K 47/55
A61K 47/69
A61P 3/08
A61K 38/28

Abstract:

The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.