Jeremy P Paige

US Patent:

20120252699, Oct 4, 2012

Filed:

Feb 18, 2010

Appl. No.:

13/202250

Inventors:

Samie R. Jaffrey - New York NY, US
Jeremy S. Paige - La Jolla CA, US

Assignee:

CORNELL UNIVERSITY - Ithaca NY

International Classification:

G01N 21/64
C12N 15/63
C12N 1/19
C12N 5/10
C12N 1/21
C07D 403/06
C12N 1/16
C12N 5/04
C12N 5/071
C07D 233/70
C07H 21/04
C07H 21/02
C40B 40/06
C12N 1/20

US Classification:

506 16, 436501, 4353201, 4352542, 435348, 435419, 4352523, 435365, 435352, 435358, 435367, 435369, 435355, 435325, 4352521, 4352551, 435410, 435 613, 5483164, 536 243, 5483245, 5483121, 5483255

Abstract:

The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.

US Patent:

20140220560, Aug 7, 2014

Filed:

Jul 27, 2012

Appl. No.:

14/235227

Inventors:

Samie R. Jaffrey - New York NY, US
Jeremy Paige - La Jolla CA, US

Assignee:

CORNELL UNIVERSITY - Ithaca NY

International Classification:

C12Q 1/68

US Classification:

435 61, 5483235, 536 231, 4352542, 435325, 435348, 435419, 5483225, 5483231

Abstract:

The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.