Mary C. Farach-Carson - Hockessin DE, US Daniel D. Carson - Hockessin DE, US Jeffrey B. Safran - Bear DE, US
Assignee:
University of Delaware - Newark DE
International Classification:
C07K 14/00
US Classification:
530350, 530300, 435 71
Abstract:
Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.
The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scalffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.
Business Administrative Law Intellectual Property Patent Procurement & Trademarks Intellectual Property Litigation
ISLN:
917585010
Admitted:
2003
University:
East Tennessee State University, 1992; University of Delaware; University of Delaware; University of Texas Graduate School of Biomedical Sciences, 1999
Law School:
Temple University Beasley School of Law, J.D.; Temple University Beasley School of Law, J.D.
Jeffrey Safran 1962 graduate of Thomas Jefferson High School in Brooklyn, NY is on Classmates.com. See pictures, plan your class reunion and get caught up with Jeffrey and other ...
Jeffrey Safran 1988 graduate of Sullivan Central High School in Blountville, TN is on Classmates.com. See pictures, plan your class reunion and get caught up with Jeffrey and other ...