Jeffrey A Greenspan

US Patent:

7521540, Apr 21, 2009

Filed:

Jan 31, 2001

Appl. No.:

10/182432

Inventors:

Lester F. Lau - Chicago IL, US
Cho-Yau Yeung - Oak Park IL, US
Jeffrey A. Greenspan - Chicago IL, US

Assignee:

Munin Corporation - Chicago IL

International Classification:

C07K 16/00

US Classification:

5303871

Abstract:

Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compositions include DNAs and RNAs comprising part, or all, of an ECM signaling molecule coding sequence, or biological equivalents. Polypeptide compositions are also provided. The polypeptide compositions comprise mammalian ECM signaling molecules, peptide fragments, inhibitory peptides capable of interacting with receptors for ECM signaling molecules, and antibody products recognizing Cyr61. Also provided are methods for producing mammalian ECM signaling molecules. Further provided are methods for using mammalian ECM signaling molecules to screen for, and/or modulate, conditions and disorders associated with angiogenesis, chondrogensis, and oncogenesis; ex vivo methods for using mammalian ECM signaling molecules to prepare blood products are also provided. Additionally, modulators, such as peptide modulators, of an ECM signaling molecule activity are provided.

US Patent:

20090081228, Mar 26, 2009

Filed:

Aug 19, 2008

Appl. No.:

12/194387

Inventors:

Lester F. Lau - Chicago IL, US
Cho-Yau Yeung - Oak Park IL, US
Jeffrey A. Greenspan - Chicago IL, US

Assignee:

MUNIN CORPORATION - Oak Park IL

International Classification:

A61K 39/395
C07K 7/08
A61K 38/10
C07H 21/00
C07K 7/06
A61K 38/08
G01N 33/53
A61P 35/00
A61K 38/16
C07K 14/00
C12N 15/63
C12N 5/00
C07K 16/00

US Classification:

4241391, 530326, 514 13, 536 235, 4353201, 435325, 5303879, 5303873, 530328, 530327, 530325, 530324, 530329, 530350, 514 16, 514 15, 514 14, 514 12, 436501

Abstract:

Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compositions include DNAs and RNAs comprising part, or all, of an ECM signaling molecule coding sequence, or biological equivalents. Polypeptide compositions are also provided. The polypeptide compositions comprise mammalian ECM signaling molecules, peptide fragments, inhibitory peptides capable of interacting with receptors for ECM signaling molecules, and antibody products recognizing Cyr61. Also provided are methods for producing mammalian ECM signaling molecules. Further provided are methods for using mammalian ECM signaling molecules to screen for, and/or modulate, conditions and disorders associated with angiogenesis, chondrogenesis, and oncogenesis; ex vivo methods for using mammalian ECM signaling molecules to prepare blood products are also provided. Additionally, modulators, such as peptide modulators, of an ECM signaling molecule activity are provided. Further provided are methods for screening for modulators of a Cyr61 polypeptide-integrin receptor interaction, as well as methods of treating conditions and disorders associated with such an interaction.