Janet R Morrow

US Patent:

20140072517, Mar 13, 2014

Filed:

May 11, 2012

Appl. No.:

14/116275

Inventors:

Janet Morrow - Williamsville NY, US
Pavel Tsitovich - Amherst NY, US

Assignee:

The Research Foundation of State University of New - Amherst NY

International Classification:

A61K 49/10
C07D 213/68
C07D 471/04
C07D 213/53

US Classification:

424 9361, 546332, 546291, 546 88, 546257, 546 2, 546 10

Abstract:

Compounds and uses of the compounds are provided. The compounds can be used as Fe(II) sequestering compounds. For example, these compounds can be used to sequester Fe(II) in cells, organs, vasculature, or tissues. Also, provided are compositions and methods of using the them for sequestering Fe(II) in an individual. The compounds can be used as MRI paraCEST contrast agents.

US Patent:

56841493, Nov 4, 1997

Filed:

Feb 17, 1995

Appl. No.:

8/390240

Inventors:

Janet R. Morrow - Williamsville NY

Assignee:

Research Foundation of State University of New York - Buffalo NY

International Classification:

C07D25700
C07F 500
C12N 510
C07H 2100

US Classification:

540474

Abstract:

The present invention provides the first examples of metal complexes that show catalytic behavior in RNA transesterification under physiological relevant conditions i. e. , 37. degree. C. and neutral pH. The metal complexes are catalytically active and kinetically inert to metal ion dissociation. The metal complexes are formed by the union of a central metal ion with a non-metallic ion or molecule. The metal ion comprises copper, zinc, cobalt, nickel, palladium, lead, iridium, maganese, iron, molybdenum, vanadium, titanium, ruthenium, bismuth, cadmium, yttrium, magnesium, rhodium, uranium, the transition metals and the Lanthanide metals. The non-metallic ion comprises a ligand or complexing agent. The preferred ligand is one which strongly chelates lanthanides, and more preferably, forms a cationic complex of the lanthanides.

US Patent:

20140193344, Jul 10, 2014

Filed:

May 11, 2012

Appl. No.:

14/116270

Inventors:

Janet R. Morrow - Williamsville NY, US
Pavel Tsitovich - Amherst NY, US
Sarina Dorazio - Elba NY, US
Abiola Olatunde - Amherst NY, US

Assignee:

The Research Foundation of State University of New York - Amherst NY

International Classification:

A61K 49/10

US Classification:

424 9363, 540465

Abstract:

Provided are macrocyclic compounds having a macrocyclic core which has at least one macrocyclic donor and at least one pendant group which has at least one donor group. The macrocyclic compounds can be complexed to Fe(II) and Ni(II). The macrocyclic compounds can be used in imaging methods. For example, the compounds can be used MRI paraCEST contrast agents.