Ioanis C Katakis

US Patent:

55433260, Aug 6, 1996

Filed:

Mar 4, 1994

Appl. No.:

8/207035

Inventors:

Adam Heller - Austin TX
Ioanis Katakis - Austin TX
Ling Ye - Mishawaka IN

International Classification:

C12M 140
C12M 134

US Classification:

4352879

Abstract:

Oxidoreductases are chemically modified so as to change their net charge at a given pH. Through such modification the adsorption of the enzymes on surfaces, their retention in similarly or oppositely charged polymer membranes and their binding with similarly or oppositely charged macromolecules, particularly redox macromolecules, is controlled. The modified enzymes, of which modified recombinant glucose oxidase is an example, are useful in biosensors, e. g. for glucose; as marker enzymes of antigens or antibodies in immunosensing; and as labels of nucleotide sequences in probes, e. g. for DNA nucleotide sequences.

US Patent:

52641058, Nov 23, 1993

Filed:

Mar 17, 1993

Appl. No.:

8/032806

Inventors:

Brian A. Gregg - Golden CO
Adam Heller - Austin TX
Wolfgang Kerner - D-2400 Lubeck 1, DE
Michael V. Pishko - Austin TX
Ioanis Katakis - San Antonio TX

International Classification:

G01N 2726

US Classification:

204403

Abstract:

An improved enzyme electrode includes a three-dimensional redox polymer network having redox enzymes bound thereto, and also having a protein excluding polymeric coating.

US Patent:

52641040, Nov 23, 1993

Filed:

May 8, 1992

Appl. No.:

7/880760

Inventors:

Brian A. Gregg - Golden CO
Adam Heller - Austin TX
Wolfgang Kerner - D-2400 Lubeck 1 TX
Michael V. Pishko - Austin TX
Ioanis Katakis - San Antonio TX

International Classification:

G01N 2726

US Classification:

204403

Abstract:

An improved enzyme electrode includes a three-dimensional redox polymer network having redox enzymes bound thereto, and also having a protein excluding polymeric coating.