Igor Ivanisevic

US Patent:

7715527, May 11, 2010

Filed:

Nov 6, 2007

Appl. No.:

11/935965

Inventors:

Igor Ivanisevic - West Lafayette IN, US
Simon Bates - West Lafayette IN, US
David E. Bugay - West Lafayette IN, US
Barbara C. Stahly - West Lafayette IN, US
Donald R. Hallenbeck - West Lafayette IN, US

Assignee:

Aptuit (Kansas City), LLC - Greenwich CT

International Classification:

G01N 23/20

US Classification:

378 70

Abstract:

A method of analyzing patterns. The method comprises: receiving a first diffraction pattern; receiving a second diffraction pattern; receiving a third diffraction pattern; determining a similarity between the first and second diffraction patterns; determining a similarity between the first and third diffraction pattern; determining a similarity between the second and third diffraction pattern; and performing hierarchical cluster analysis on the first and second diffraction pattern based on the determined similarity.

US Patent:

7372941, May 13, 2008

Filed:

Aug 6, 2003

Appl. No.:

10/635113

Inventors:

Igor Ivanisevic - West Lafayette IN, US
Simon Bates - West Lafayette IN, US
David E. Bugay - West Lafayette IN, US
Barbara C. Stahly - West Lafayette IN, US
Donald R. Hallenbeck - West Lafayette IN, US

Assignee:

SSCI, Inc. - West Lafayette IN

International Classification:

G01N 23/20

US Classification:

378 70

Abstract:

A method of analyzing patterns. The method comprises: receiving a first diffraction pattern; receiving a second diffraction pattern; receiving a third diffraction pattern; determining a similarity between the first and second diffraction patterns; determining a similarity between the first and third diffraction pattern; determining a similarity between the second and third diffraction pattern; and performing hierarchical cluster analysis on the first and second diffraction pattern based on the determined similarity.

US Patent:

8252947, Aug 28, 2012

Filed:

Apr 3, 2009

Appl. No.:

12/418559

Inventors:

Steven K. White - San Diego CA, US
Igor Ivanisevic - West Lafayette IN, US
Kyle Stephens - West Lafayette IN, US
Mark Andres - West Lafayette IN, US
Brenton Skylar Wolfe - West Lafayette IN, US

Assignee:

Harbor Therapeutics, Inc. - San Diego CA

International Classification:

C07J 5/00
C07J 7/00
A61K 31/56

US Classification:

552562, 514182

Abstract:

The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β, 7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5-ene-3β, β,17β-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17α-ethynyl-androst-5-ene-3β,7β,17β-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-androst-5-ene-3β, 7β,17β-triol and uses of such formulations in treating the described conditions.

US Patent:

8410127, Apr 2, 2013

Filed:

Sep 20, 2010

Appl. No.:

12/886470

Inventors:

Jiangao Song - Hayward CA, US
Charles A. McWherter - Hayward CA, US
Fang Ma - Hayward CA, US
Mark Andres - West Lafayette IN, US
Igor Ivanisevic - West Lafayette IN, US
Ekaterina Albert - West Lafayette IN, US
Patricia Andres - West Lafayette IN, US

Assignee:

Metabolex, Inc. - Hayward CA

International Classification:

A01N 43/54
A61K 31/505

US Classification:

514275, 544331

Abstract:

Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

US Patent:

8524782, Sep 3, 2013

Filed:

Jan 21, 2011

Appl. No.:

13/011593

Inventors:

Gottumukkala V. Subbaraju - Tirupati, IN
Masna Mahesh - Hyderabad, IN
Hindupur R. Mohan - Hyderabad, IN
Thatipally Suresh - Hyderabad, IN
Igor Ivanisevic - West Lafayette IN, US
Mark Andres - West Lafayette IN, US
Kyle Stephens - Farmland IN, US

Assignee:

Laurus Labs Private Limited

International Classification:

A01N 31/14
A61K 31/075

US Classification:

514720, 568646, 568729, 549416

Abstract:

The present invention provides a scalable process for the preparation of stilbenes by (i) condensing 3,5-dialkylbenzyl phosphonates with 4′-O-tetrahydropyranyl benzaldehyde to get 3,5-alkyl-4′-O-tetrahydropyranyl Stilbene and (ii) deprotecting the obtained 3,5-Dialkyl-4′-O-tetrahydropyranylstilbene to yield stilbenes. The present invention also provides a novel intermediate 3,5-Dialkyl-4′-O-tetrahydropyranyl stilbene, which is a key intermediate for the synthesis of stilbenes such as Pterostilbene and Resveratrol. The present invention also provides characteristics of various solid forms of Pterostilbene, methods for their preparation, as well as dosage forms containing the same for administration to or consumption by humans.

US Patent:

20070243620, Oct 18, 2007

Filed:

Feb 24, 2005

Appl. No.:

10/590204

Inventors:

Simon Bates - West Lafayette IN, US
Igor Ivanisevic - West Lafayette IN, US

International Classification:

G01N 23/20
G06F 19/00
G11C 17/00

US Classification:

436057000, 365094000, 702019000

Abstract:

A method that comprises providing a PDF trace of a first sample of a substance, providing a PDF trace of a second sample of the substance, and comparing the PDF traces to determine whether the substance of the first sample and the substance of the second sample have the same or different solid forms. This embodiment may be used, for example, to distinguish one solid form of a compound from another, to screen for new solid forms of a compound, or to determine whether a disordered crystalline compound has the same solid form as another crystalline sample of the compound.

US Patent:

20070270397, Nov 22, 2007

Filed:

Oct 27, 2004

Appl. No.:

10/577239

Inventors:

Simon Bates - West Lafayette IN, US
Igor Ivanisevic - West Lafayette IN, US
Barbara Stahly - West Lafayette IN, US

International Classification:

A01N 43/00

US Classification:

514210010, 514241000, 702019000, 514649000

Abstract:

Crystalline solid forms may be characterized by their unit cell parameters through a process known as indexing. An embodiment of the invention searches for the unit cell parameters of a crystalline solid form using a Monte-Carlo algorithm that incorporates certain rules to reduce search space. Another embodiment refines the results of the search to identify the correct unit cell parameters of the crystalline solid form. These methods may be automated, conveniently requiring little interaction from the user. The indexing method of the invention may be applied, for example, to distinguish between different crystalline solid forms of a substance.

US Patent:

20120296105, Nov 22, 2012

Filed:

Aug 1, 2012

Appl. No.:

13/563982

Inventors:

Steven K. White - San Diego CA, US
Igor Ivanisevic - West Lafayette IN, US
Kyle Stephens - West Lafayette IN, US
Mark Andres - West Lafayette IN, US
Brenton Skylar Wolfe - West Lafayette IN, US

Assignee:

Harbor Therapeutics, Inc. - San Diego CA

International Classification:

C07J 75/00
C07J 1/00

US Classification:

552615

Abstract:

The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17α-ethynyl-androst-5-ene-3β,7β,17β-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol and uses of such formulations in treating the described conditions.