Ichiro C Nishimura

US Patent:

7067169, Jun 27, 2006

Filed:

Jun 4, 2003

Appl. No.:

10/454406

Inventors:

Jiankai Liu - Chartsworth CA, US
Yuhong Huang - West Hills CA, US
Ichiro Nishimura - Santa Monica CA, US

Assignee:

Chemat Technology Inc. - Northrdige CA

International Classification:

G01N 1/31

US Classification:

427 213, 422 57, 623 142

Abstract:

A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer that promotes osseointegration. An apparatus comprising a substrate having a dimension suitable as a medical or dental implant and a coating on a surface of a first coating layer derived from an alkoxide and a second coating layer that promotes osseointegration.

US Patent:

7341756, Mar 11, 2008

Filed:

Feb 22, 2006

Appl. No.:

11/360144

Inventors:

Jiankai Liu - Chartsworth CA, US
Yuhong Huang - West Hills CA, US
Ichiro Nishimura - Santa Monica CA, US

Assignee:

Chemat Technology, Inc. - Northridge CA

International Classification:

G01N 1/31

US Classification:

427 213, 623 142

Abstract:

A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer that promotes osseointegration. An apparatus comprising a substrate having a dimension suitable as a medical or dental implant and a coating on a surface of a first coating layer derived from an alkoxide and a second coating layer that promotes osseointegration.

US Patent:

7648726, Jan 19, 2010

Filed:

Mar 6, 2008

Appl. No.:

12/043865

Inventors:

Jiankai Liu - Chartsworth CA, US
Yuhong Huang - West Hills CA, US
Ichiro Nishimura - Santa Monica CA, US

Assignee:

Chemat Technology, Inc. - Northridge CA

International Classification:

G01N 1/31
A61C 13/08
A61F 2/02

US Classification:

427 213, 433216, 623 1111

Abstract:

A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer that promotes osseointegration. An apparatus comprising a substrate having a dimension suitable as a medical or dental implant and a coating on a surface of a first coating layer derived from an alkoxide and a second coating layer that promotes osseointegration.

US Patent:

20020197640, Dec 26, 2002

Filed:

Jun 19, 2002

Appl. No.:

10/174658

Inventors:

Ichiro Nishimura - Los Angeles CA, US
Keisuke Iida - Los Angeles CA, US

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/023500, 536/023200

Abstract:

The present invention provides an improved method for assessing, monitoring and/or determining the phenotype of cells and tissues. One aspect of the present invention is a method of fabricating phenotype specific gene (PSGs) and house keeping gene (HKGs) targets onto a microarray. Another aspect of the present invention provides a composition containing PSGs and HKGs as targets for high throughput assays including microarray analyses. Another aspect of the present invention is accessing, monitoring and/or determining the phenotype of tissue engineered cells derived from stem cells including embryonic stem cells, embryonic germ cells, fetal stem cells and adult stem cells by hybridizing cDNA probes to either PSG or HKG targets. These methods employ at least 25 PSG targets and no greater than 5000 HKG targets.

US Patent:

20030092030, May 15, 2003

Filed:

Jun 12, 2002

Appl. No.:

10/170786

Inventors:

Ichiro Nishimura - Los Angeles CA, US
Cortino Sukotjo - Los Angeles CA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/64
C12P021/02
C12N005/06

US Classification:

435/006000, 435/069100, 435/226000, 435/320100, 435/325000, 536/023200

Abstract:

The present invention provides a method of treatment to improve wound healing and to minimize/prevent abnormal scarring caused by tissue contraction and fibrosis formation by providing a specific gene, Wit 3.0 alpha and beta sequences that is differentially expressed in wounded oral mucosa cells, relative to their decreased expression in non-wounded oral mucosa cells. One aspect of the invention is a method to treat soft tissue wound using anti-sense nucleic acid technologies. Another aspect of the present invention is a method to treat soft tissue wound using sense nucleic acid technologies. These methods can employ a complimentary nucleic acid sequence that is greater than 85% identity to Wit 3.0 alpha and/or beta sequences or greater than 90% identity to the deduced amino acids thereof.

US Patent:

20090264507, Oct 22, 2009

Filed:

Mar 10, 2006

Appl. No.:

11/817339

Inventors:

Ichiro Nishimura - Santa Monica CA, US
Audrey Lin - Los Angeles CA, US
Neal Garret - Moorpark CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 31/7088
C12Q 1/68
C07H 21/04
C07K 16/18
A61P 1/02

US Classification:

514 44 R, 435 6, 536 2433, 5303875

Abstract:

The present invention provides methods for diagnosing and providing a prognosis for wound healing in a patient by characterizing and analyzing the single nucleotide polymorphism (SNP) of a wound healing associated gene wit3.0. In particular, the invention provides a method of diagnosis and prognosis of oral disease-wound healing, including gingival periodontitis and residual alveolar bone resorption, by characterizing and analyzing the wound inducible transcript-3.0 (wit3.0)SNP pattern in a sample of a patient with and without susceptibility for the disease.

US Patent:

20120165263, Jun 28, 2012

Filed:

Sep 3, 2010

Appl. No.:

13/394263

Inventors:

Takahiro Hiratsuka - Ashigarakami-gun, JP
Shouji Ooya - Ashigarakami-gun, JP
Ichiro Nishimura - Santa Monica CA, US

Assignee:

FUJIFILM CORPORATION - Minato-ku, Tokyo

International Classification:

A61K 38/39
A61P 19/08
A61P 19/02
A61P 19/10

US Classification:

514 169, 514 167

Abstract:

It is an object of the present invention to provide a bone regeneration agent and a bone supplementation formulation, in which a supplementation material itself is capable of promoting bone regeneration. The present invention provides a bone regeneration agent which comprises a gelatin having an amino acid sequence derived from a partial amino acid of collagen.

US Patent:

20200030457, Jan 30, 2020

Filed:

Apr 2, 2018

Appl. No.:

16/498301

Inventors:

- Oakland CA, US
Ichiro Nishimura - Venice CA, US
Naren Subbiah - Danville CA, US
Jesus Campagna - Playa Del Rey CA, US
Patricia R. Spilman - Mill Valley CA, US
Mohammad Parvez Alam - Los Angeles CA, US

International Classification:

A61K 47/69
A61K 47/24
A61K 47/28
A61K 47/54
A61K 47/22
A61K 47/26
A61K 47/62

Abstract:

In various embodiments deformable nano-scale vehicles (DNV) are provided that are useful for the delivery of therapeutic agents. In certain embodiments the DNVs are capable of transdermal delivery and can additionally cross the blood-brain barrier.