Honghe H Wan

US Patent:

8202881, Jun 19, 2012

Filed:

Sep 2, 2010

Appl. No.:

12/874276

Inventors:

Ashok V. Purandare - Pennington NJ, US
James W. Grebinski - Lawrenceville NJ, US
Amy Hart - Ewing NJ, US
Jennifer Inghrim - Plainsboro NJ, US
Gretchen Schroeder - Ewing NJ, US
Honghe Wan - Pennington NJ, US

Assignee:

Bristol-Meyers Squibb Company - Princeton NJ

International Classification:

A61K 31/437
C07D 471/14
C07D 471/16

US Classification:

514290, 546 82, 546 85, 546 87

Abstract:

The present invention provides compounds of formula I.

US Patent:

20030139431, Jul 24, 2003

Filed:

Sep 21, 2002

Appl. No.:

10/253946

Inventors:

Joel Kawakami - Newfoundland NJ, US
John Wetzel - Fairlawn NJ, US
Lakmal Boteju - Cedar Grove NJ, US
Michael Konkel - Garfield NJ, US
Honghe Wan - Kearny NJ, US
Stewart Noble - Lake Forest IL, US

International Classification:

A61K031/517
A61K031/47

US Classification:

514/266400, 514/313000

Abstract:

This invention provides compounds having the structure: wherein X=CH, C(CH) or N; each of R, R, R, Rand Ris independently H, C-Cstraight chained or branched alkyl, C-Cstraight chained or branched alkenyl, C-Cstraight chained or branched alkynyl, C-Ccycloalkyl, substituted or unsubstituted aryl, hydroxy, halogenated ether, nitro, amino, halogen, —CN, —C( Z)R, —C( Z)OR, —C( Z)N(R), —N(R)—C( Z)R, —N(R)—C( Z)N(R), —OC( Z)R, —C( Z)OR—ORor —SR; wherein Z is O or S; and wherein Ris C-Cstraight chained or branched alkyl, aryl, (CH)Q, C-Calkenyl, C-Ccycloalkyl, C-Ccycloalkenyl, wherein Q is OR, SR, N(R)or aryl, wherein Ris H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, wherein Rand Rand the carbons to which they are attached form a fused aryl, heteroaryl, C-Ccyclic alkyl or heterocyclic alkyl ring; or wherein Rand Rand the carbons to which they are attached form a fused aryl, heteroaryl, cyclic alkyl or heterocyclic alkyl ring; and wherein each alkyl, alkenyl, alkynyl and alkoxy group is optionally substituted with a substituent independently selected from R, where Ris 1) hydroxy, 2) C-Calkoxy, 3) halogen, 4) nitro, 5) amino, 6) CF, or 7) carboxy, and each cycloalkyl group is optionally substituted with a substituent independently selected from R, where Ris 1) a group selected from R, 2) C-Calkyl, 3) C-Calkenyl, 4) C-Calkynyl or 5) cyclic C-Calkyl, and each aryl is optionally substituted with R. This invention also provides methods of treating pain, urge incontinence; as well as methods of preparing the compounds.

US Patent:

20030176314, Sep 18, 2003

Filed:

Sep 24, 2002

Appl. No.:

10/253237

Inventors:

Carlos Forray - Paramus NJ, US
Joel Kawakami - Newfoundland NJ, US
Michael Konkel - Garfield NJ, US
Lakmal Boteju - Cedar Grove NJ, US
John Wetzel - Fairlawn NJ, US
Stewart Noble - Lake Forest IL, US
Honghe Wan - Kearny NJ, US

International Classification:

A61K031/00

US Classification:

514/001000

Abstract:

This invention provides methods of treating pain, urinary incontinence and other abnormalities mediated by a NPFF receptor, which comprises administering to a subject a therapeutically effective amount of a chemical compound which acts at the NPFF1 receptor, the NPFF2 receptor, or at both the NPFF1 and NPFF2 receptors.

US Patent:

20060235037, Oct 19, 2006

Filed:

Apr 13, 2006

Appl. No.:

11/403790

Inventors:

Ashok Purandare - Pennington NJ, US
Honghe Wan - Pennington NJ, US
Tram Huynh - Pennington NJ, US

International Classification:

A61K 31/4747
A61K 31/46
A61K 31/454
A61K 31/4184
A61K 31/404
C07D 403/02

US Classification:

514278000, 514304000, 514314000, 514337000, 514338000, 546015000, 546125000, 546176000, 546201000, 514394000, 548305400, 548465000, 546199000

Abstract:

A compound of formula I, or a stereoisomer, a tautomer, a pharmaceutically acceptable salt or solvate thereof, methods of using such compounds in the treatment of hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases; and to pharmaceutical compositions containing such compounds.

US Patent:

20080045496, Feb 21, 2008

Filed:

Aug 8, 2007

Appl. No.:

11/835456

Inventors:

Brian Fink - Yardley PA, US
Ping Chen - Belle Mead NJ, US
Ashok Purandare - Pennington NJ, US
Honghe Wan - Pennington NJ, US

International Classification:

A61K 31/53
A61K 31/5377
A61P 35/00
C07D 487/04

US Classification:

514210210, 514233200, 514243000, 544112000, 544183000

Abstract:

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of such as TrkA, TrkB, TrkC, Jak2, Jak3 and CK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

US Patent:

20130225551, Aug 29, 2013

Filed:

Apr 30, 2012

Appl. No.:

13/459742

Inventors:

Ashok V. Purandare - Pennington NJ, US
James W. Grebinski - Lawrenceville NJ, US
Amy Hart - Ewing NJ, US
Jennifer Inghrim - Plainsboro NJ, US
Gretchen Schroeder - Ewing NJ, US
Honghe Wan - Pennington NJ, US

International Classification:

A61K 31/437
A61K 31/5377
A61K 45/06
A61K 31/496
A61K 31/541
C07D 471/14
C07D 513/04

US Classification:

51421018, 514293, 5142328, 51425303, 51421021, 5142285

Abstract:

The present invention provides compounds of formula Iand pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

US Patent:

20140018319, Jan 16, 2014

Filed:

Jul 12, 2013

Appl. No.:

13/940619

Inventors:

Brian E. Fink - Yardley PA, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Walter Lewis Johnson - Waterbury CT, US
Amy C. Hart - Ewing NJ, US
Liqi He - Furlong PA, US
Tram N. Huynh - Pennington NJ, US
Jennifer Inghrim - Plainsboro NJ, US
Harold Mastalerz - Guildford CT, US
Xiaopeng Sang - Glastonbury CT, US
Christine M. Tarby - Lawrenceville NJ, US
Honghe Wan - Pennington NJ, US
Wayne Vaccaro - Yardley PA, US
Guifen Zhang - Wallingford CT, US
Yufen Zhao - Pennington NJ, US
Kurt Zimmermann - Durham CT, US

International Classification:

A61K 31/675
A61K 31/53
A61K 31/551
A61K 31/5377
C07D 487/10
C07F 9/6521
C07D 498/04
A61K 31/5383
A61K 45/06
C07D 487/04
C07D 471/10

US Classification:

514 81, 544184, 514243, 540575, 544112, 5142332, 51421021, 51421002, 51421018, 5142325, 544 81, 544105, 5142305

Abstract:

The invention provides compounds of Formula (I)and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.

US Patent:

20220306630, Sep 29, 2022

Filed:

Aug 5, 2020

Appl. No.:

17/632909

Inventors:

- Princeton NJ, US
Peter Kinam Park - New York NY, US
Zheming Ruan - Dayton NJ, US
Donna D. Wei - Belle Mead NJ, US
Daniel O'Malley - New Hope PA, US
Honghe Wan - Pennington NJ, US
Ashok Vinayak Purandare - Pennington NJ, US
Brian E. Fink - Yardley PA, US

International Classification:

C07D 471/10
C07C 317/18
C07D 213/73
C07D 213/71
C07C 255/60
C07D 213/82
C07D 231/12
C07D 231/18
C07D 263/24
C07D 213/56
C07D 401/12
C07C 311/16
C07D 213/69
C07D 233/61
C07D 211/34
C07D 235/18
C07D 213/58
C07D 211/96
C07D 295/26

Abstract:

The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.