Guoxun Chen

age ~57

from Carrollton, TX

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Also known as:

4345 Mesa Dr, Carrollton, TX 75010

Connected to:

Methods And Compositions For Stat-1 Conferred Resistance To Immunotoxicity
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US Patent:

20020141979, Oct 3, 2002
Filed:

Apr 10, 2001
Appl. No.:

09/833205
Inventors:

Guoxun Chen - Carrollton TX, US
Christopher Newgard - Dallas TX, US
International Classification:

A61K048/00
C12N005/08
C12N015/86
US Classification:

424/093210, 435/456000, 435/366000
Abstract:

The present invention describes methods and compositions for preventing immuno-cytotoxicity of transplanted cells. The invention provides cells and expression constructs encoding STAT-1 polypeptides that prevent cytokine-mediated cytotoxicity. Thus, the invention provides treatment methods for preventing the rejection of transplanted cells by a host. In a particular embodiment, the invention provides for treatment of diabetes by transplanting into a subject insulinoma cells that secrete insulin in response to glucose and further express STAT-1, thereby conferring resistance to inflammatory cytokines involved in the cell-rejection response.

Methods And Compositions Relating To No-Mediated Cytotoxicity
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US Patent:

61718564, Jan 9, 2001
Filed:

Jul 30, 1998
Appl. No.:

9/126109
Inventors:

Anice Thigpen - Dallas TX
Hans-Ewald Hohmeier - Dallas TX
Christopher B. Newgard - Dallas TX
Roger H. Unger - Dallas TX
Michio Shimabukuro - Okinawa, JP
Guoxun Chen - Dallas TX
Christopher J. Rhodes - Dallas TX
Sigrun R. Hugl - Irving TX
Sharon Cousin - Irving TX
Assignee:

Board of Regents, The University of Texas System - Austin TX
Betagene, Inc - Dallas TX
International Classification:

C12N 1500
US Classification:

435325
Abstract:

The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic intervention of diabetes. The present invention demonstrates that MnSOD can play a protective role against cytokine killing, and provides strategies for engineering cell lines as islet surrogates for transplantation therapy of diabetes mellitus. Further, the present invention shows that. beta. -cell destruction and dysfunction in adipogenic diabetes is mediated via fatty acids. Methods and compositions for ameliorating this disorder are provided herein.

Guoxun Chen Phones & Addresses