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Guoxun Chen

age ~56

from Carrollton, TX

Also known as:
  • N Chen
  • R Chen
  • Guoxun Yuan
  • Xun Chen Guo
  • Chen Guoxun
4345 Mesa Dr, Carrollton, TX 75010

Guoxun Chen Phones & Addresses

  • 4345 Mesa Dr, Carrollton, TX 75010
  • Dallas, TX
  • Knoxville, TN
  • Garland, TX

Us Patents

  • Methods And Compositions For Stat-1 Conferred Resistance To Immunotoxicity

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  • US Patent:
    2002014, Oct 3, 2002
  • Filed:
    Apr 10, 2001
  • Appl. No.:
    09/833205
  • Inventors:
    Guoxun Chen - Carrollton TX,
    Christopher Newgard - Dallas TX,
  • International Classification:
    A61K048/00
    C12N005/08
    C12N015/86
  • US Classification:
    424/093210, 435/456000, 435/366000
  • Abstract:
    The present invention describes methods and compositions for preventing immuno-cytotoxicity of transplanted cells. The invention provides cells and expression constructs encoding STAT-1 polypeptides that prevent cytokine-mediated cytotoxicity. Thus, the invention provides treatment methods for preventing the rejection of transplanted cells by a host. In a particular embodiment, the invention provides for treatment of diabetes by transplanting into a subject insulinoma cells that secrete insulin in response to glucose and further express STAT-1, thereby conferring resistance to inflammatory cytokines involved in the cell-rejection response.
  • Methods And Compositions Relating To No-Mediated Cytotoxicity

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  • US Patent:
    6171856, Jan 9, 2001
  • Filed:
    Jul 30, 1998
  • Appl. No.:
    9/126109
  • Inventors:
    Anice Thigpen - Dallas TX
    Hans-Ewald Hohmeier - Dallas TX
    Christopher B. Newgard - Dallas TX
    Roger H. Unger - Dallas TX
    Michio Shimabukuro - Okinawa,
    Guoxun Chen - Dallas TX
    Christopher J. Rhodes - Dallas TX
    Sigrun R. Hugl - Irving TX
    Sharon Cousin - Irving TX
  • Assignee:
    Board of Regents, The University of Texas System - Austin TX
    Betagene, Inc - Dallas TX
  • International Classification:
    C12N 1500
  • US Classification:
    435325
  • Abstract:
    The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic intervention of diabetes. The present invention demonstrates that MnSOD can play a protective role against cytokine killing, and provides strategies for engineering cell lines as islet surrogates for transplantation therapy of diabetes mellitus. Further, the present invention shows that. beta. -cell destruction and dysfunction in adipogenic diabetes is mediated via fatty acids. Methods and compositions for ameliorating this disorder are provided herein.

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