Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
Radioimmunotherapy Of Lymphoma Using Anti-Cd20 Antibodies
Mark S. Kaminski - Ann Arbor MI Gregory M. Butchko - Miami Lakes FL Stephan D. Glenn - Davie FL Richard L. Wahl - Ann Arbor MI
Assignee:
Coulter Pharmaceutical, Inc. - South San Francisco CA The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 5110 A61K 39395 C07K 1600
US Classification:
424 149
Abstract:
Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy also described is a composition useful in the treatment of lymphoma.
Radioimmunotherapy Of Lymphoma Using Anti-Cd20 Antibodies
Mark S. Kaminski - Ann Arbor MI Gregory M. Butchko - Miami Lakes FL Stephan D. Glenn - Davie FL Richard L. Wahl - Ann Arbor MI
Assignee:
Coulter Pharmaceutical, Inc. - So. San Francisco CA Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 5110 A61K 4505 C07K 1600
US Classification:
424 149
Abstract:
Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
Radioimmunotherapy Of Lymphoma Using Anti-Cd20 Antibodies
Mark S. Kaminski - Ann Arbor MI Gregory M. Butchko - Miami Lakes FL Stephan D. Glenn - Davis FL Richard L. Wahl - Ann Arbor MI
Assignee:
Coulter Pharmaceutical, Inc. - Palo Alto CA Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 5110 C07K 1600
US Classification:
424 149
Abstract:
Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
Radioimmunotherapy Of Lymphoma Using Anti-Cd20 Antibodies
Mark S. Kaminski - Ann Arbor MI Gregory M. Butchko - Lake Forest IL Stephan D. Glenn - Sunnyvale CA Richard L. Wahl - Ann Arbor MI
Assignee:
The Regents of the University of Michigan - Ann Arbor MI Coulter Pharmaceutical, Inc. - South San Francisco CA
International Classification:
A61K 5100 A61K 39395 C12P 2108 C07K 1600
US Classification:
424 149
Abstract:
Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
Process And Apparatus For Removal Of Dna, Viruses And Endotoxins
Stephan D. Glenn - Davie FL Gregory Butchko - Miami Lakes FL Edward O'Connell - Miami FL Paulette Smariga - North Miami FL
Assignee:
Coulter Corporation - Hialeah FL
International Classification:
B01D 2500 B01D 6308 B01D 7110
US Classification:
210641
Abstract:
A single filtration device containing coated filter membranes and absolute pore filters is provided in which the membranes and absolute pore filters are present in two sections of the filter device. The filter device will remove up to about 98% of the endotoxins in addition to removing viruses with an efficiency of at least 4. 6. times. 10. sup. 5 and DNA to less than 10 picograms per 500 mg sample.
Process And Apparatus For Removal Of Dna And Viruses
Stephan D. Glenn - Davie FL Edward O'Connell - Miami FL Paulette Smariga - Miami Lakes FL Gregory Butchko - Miami Lakes FL
Assignee:
Coulter Corporation - Hialeah FL
International Classification:
B01D 2500 B01D 6308 B01D 7110
US Classification:
210641
Abstract:
A single filtration device containing coated filter membranes and absolute pore filters is provided in which the membranes and absolute pore filters are present in two sections of the filter device. The filter device will remove viruses, as modeled by type-C Xenotropic retrovirus, with an efficiency of at least 4. 6. times. 10. sup. 5 ; remove DNA from levels of 10. mu. g/sample to levels below 10 picograms per 500 mg sample of monoclonal antibody; and will remove at least 97% of some bacterial endotoxins.
Mark S. Kaminski - Ann Arbor MI Gregory M. Butchko - Miami Lakes FL Stephan D. Glenn - Davie FL Richard L. Wahl - Ann Arbor MI
Assignee:
Coulter Pharmaceutical, Inc. - Palo Alto CA
International Classification:
A61K 5110
US Classification:
424 149
Abstract:
Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
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Gregory Butchko
WEST DEER CAMP LIMITED LIABILITY COMPANY
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