Gregory R Bogart

US Patent:

59553774, Sep 21, 1999

Filed:

Apr 17, 1995

Appl. No.:

8/403565

Inventors:

Diana M. Maul - Thornton CO
Gregory R. Bogart - Fort Collins CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543
G01N 33547

US Classification:

436518

Abstract:

Method for detecting an analyte of interest, comprising the steps of providing a detection device comprising a light reflective or transmissive substrate supporting one or more layers comprising an adhering attachment layer to which is affixed a receptive material which specifically interacts with the analyte of interest; reacting the device with a sample potentially comprising the analyte under conditions in which the analyte binds to the receptive material; and reacting bound analyte with a reagent which creates a mass change on the surface of the device.

US Patent:

54828309, Jan 9, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/076320

Inventors:

Gregory R. Bogart - Berthoud CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33544
C12Q 100

US Classification:

435 5

Abstract:

Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface of any amount selected from 0. 1 nM, 0. 1 ng/ml, 50 fg, and 2. times. 10. sup. 3 organisms comprising the analyte.

US Patent:

54948010, Feb 27, 1996

Filed:

Dec 3, 1993

Appl. No.:

8/162401

Inventors:

Gregory R. Bogart - Berthoud CO
Robert J. Bilodeau - Arvada CO
Rachel M. Ostroff - Westminster CO
Jeffrey W. Steaffens - Louisville CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33569

US Classification:

435 734

Abstract:

Method for extracting an antigen from a micro-organism organism of the genus streptococcus contained in a sample including the steps of contacting the sample with reagents which generate hyponitrous acid, further contacting the sample with a base, or contacting the sample with hypochlorite, and neutralizing the sample.

US Patent:

55522726, Sep 3, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/076348

Inventors:

Gregory R. Bogart - Berthoud CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543

US Classification:

435 6

Abstract:

Device for detecting the presence or amount of an analyte of interest, comprising a reflective solid, optical support and a label capable of generating fluorescent signal upon excitation with a suitable light source wherein said support comprises an attachment layer comprising a chemical selected from the group consisting of dendrimers, star polymers, molecular self-assembling polymers, polymeric siloxanes, and film forming latexes wherein the support provides an enhanced level of exciting photons to the immobilized fluorescent label compound, and wherein the support also increases the capture of fluorescent signal.

US Patent:

55500633, Aug 27, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/076347

Inventors:

Gregory R. Bogart - Berthoud CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543

US Classification:

436518

Abstract:

Method for producing an optical assay device having a substrate and one or more optical layers, an attachment layer and a receptive layer, including the step of spin coating an anti-reflective layer or an attachment layer.

US Patent:

55410570, Jul 30, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/075952

Inventors:

Gregory R. Bogart - Berthoud CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO
Mark Crosby - Niwot CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

C12Q 170
G01N 3353
G01N 33543
G01N 2100

US Classification:

435 5

Abstract:

Method for detecting the presence or amount of an analyte of interest in a sample by providing a substrate having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in an amount selected from any one of 0. 1 nM, 0. 1 ng/ml, 50 fg, 2. times. 10. sup. 3 organisms comprising the analyte; and contacting the optically active surface with a sample potentially comprising the analyte of interest under conditions in which the analyte can interact with the optically active surface to cause the optically active surface to exhibit the second color when the analyte is present.

US Patent:

58692720, Feb 9, 1999

Filed:

May 31, 1995

Appl. No.:

8/455652

Inventors:

Gregory R. Bogart - Berthoud CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO
Mark Crosby - Niwot CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33551
G01N 33552
G01N 33569

US Classification:

435 732

Abstract:

Method for the determination of chlamydial or gram negative bacterial antigen comprising contacting a sample potentially containing extracted antigen with an optically active surface comprising an attachment layer, and a layer of non-specific protein.