Goetz D Hardtmann

US Patent:

39594831, May 25, 1976

Filed:

Aug 22, 1975

Appl. No.:

5/606930

Inventors:

Goetz E. Hardtmann - Morristown NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

A61K 31275
C07C12175

US Classification:

424304

Abstract:

Sedative/hypnotics of the formula ##SPC1## Wherein R is hydrogen, halo, alkyl, alkoxy or trifluoromethyl, are prepared by reacting a phenyl-2,3-epoxypropyl ether with methyl isocyanide.

US Patent:

41873092, Feb 5, 1980

Filed:

Jun 20, 1977

Appl. No.:

5/807914

Inventors:

Goetz E. Hardtmann - Morristown NJ

Assignee:

Sandoz, Inc. - East Hanover NJ

International Classification:

A61K 3147

US Classification:

424258

Abstract:

Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof, e. g. , 1-allyl-6,7-dimethoxy-4-hydroxy-2-quinolinone-3-carboxylic acid, useful as anti-allergic agents, and prepared by hydrolysis of the corresponding carboxylic acid esters.

US Patent:

39311830, Jan 6, 1976

Filed:

Jul 24, 1974

Appl. No.:

5/491249

Inventors:

Goetz E. Hardtmann - Florham Park NJ

Assignee:

Sandoz Inc. - E. Hanover NJ

International Classification:

C07D23900

US Classification:

2602564F

Abstract:

Anti-histaminics of the formula ##SPC1## Wherein R. sub. 1 is alkyl, alkenyl or phenalkyl, R. sub. 2 and R. sub. 3 are alkyl or alkenyl and R' is optional are prepared by alkylating or alkenylating a 1-substituted-2-monosubstituted-amino pyrido 2,3-d pyrimidin-4(1H)-one with an alkyl halide or alkenyl halide.

US Patent:

39949184, Nov 30, 1976

Filed:

Jun 17, 1975

Appl. No.:

5/587534

Inventors:

Goetz E. Hardtmann - Florham Park NJ

Assignee:

Sandoz, Inc. - East Hanover NJ

International Classification:

C07D26322

US Classification:

260307C

Abstract:

The invention discloses compounds of the class of 5-substituted-5H-dibenzo[a,d]cycloheptenes which are 5-hydrazinoalkyl- or 5-aminoalkyl-5H-dibenzo[a,d]cyclohepten-5-ols, or their 10,11-dihydro derivatives. The compounds are pharmaceutically active and useful, for example, as anti-convulsants and tranquilizers. A key intermediate are compounds which are a spiro[5H-dibenzo[a,d]cyclohepten-5-oxazolin-2-one] which are subjected to alkaline hydrolysis to obtain the compounds of the invention.

US Patent:

41171373, Sep 26, 1978

Filed:

Jul 6, 1977

Appl. No.:

5/813266

Inventors:

Goetz E. Hardtmann - Morristown NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

A61K 3144

US Classification:

424263

Abstract:

2-Amino-3-pyridyl (or phenyl) nitromethylketones are prepared eg by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido [2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitromethane with a porton abstracting agent. The compounds are useful as anti-allergic agents.

US Patent:

44514646, May 29, 1984

Filed:

Sep 29, 1982

Appl. No.:

6/427282

Inventors:

Goetz E. Hardtmann - Morristown NJ
William J. Houlihan - Mt. Lakes NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

A61K 31505
C07D48704

US Classification:

424251

Abstract:

Tranquilizers are of the formula: ##STR1## wherein R. degree. is alkyl of 1 to 8 carbon atoms, and n is 1 or 2.

US Patent:

48701998, Sep 26, 1989

Filed:

Mar 10, 1988

Appl. No.:

7/166594

Inventors:

Goetz E. Hardtmann - Morristown NJ
Prasad K. Kapa - Parsippany NJ
George T. Lee - Bloomfield NJ
Jerome Linder - Westfield NJ
Sompong Wattanasin - Hopatcong NJ

Assignee:

Sandoz Pharm. Corp. - E. Hanover NJ

International Classification:

C07F 718

US Classification:

556437

Abstract:

Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P. sub. 1 is independently an hydroxy group-protecting group, and R. sub. 2z is C. sub. 1-4 alkyl, benzyl or allyl, comprising, as a key step when R. sub. 2z is R. sub. 2x, the reaction of the compound of the formula ##STR2## in (S) enantiomeric form with a compound of the formula Mg. sup. . circle. +2 (. sup. crclbar. OOC--CH. sub. 2 --COOR. sub. 2x). sub. 2 to obtain a compound of the formula ##STR3## in (S) enantiomeric form, and, as a key step when R. sub. 2z is R. sub. 2y, the reaction of a compound of the formula ##STR4## in (S) enantioimeric form with a compound of the formula Li. sup. sym. crclbar. CH. sub. 2 --COOR. sub. 2y to obtain a compound of the formula ##STR5## in (S) enantiomeric form, wherein R. sub. 2x is primary or secondary C. sub.

US Patent:

42811317, Jul 28, 1981

Filed:

Jul 16, 1979

Appl. No.:

6/057962

Inventors:

Goetz E. Hardtmann - Morristown NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07D491056
C07D21522

US Classification:

546 90

Abstract:

Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof, e. g. , 1-allyl-6,7-dimethoxy-4-hydroxy-2-quinolinone-3-carboxylic acid, useful as anti-allergic agents, and prepared by hydrolysis of the corresponding carboxylic acid esters.