George Andrew Inana

US Patent:

8158600, Apr 17, 2012

Filed:

Aug 13, 2009

Appl. No.:

12/583073

Inventors:

George Inana - Miami FL, US
Margaret Jean McLaren - Miami FL, US

International Classification:

C12N 15/11

US Classification:

514 44A

Abstract:

The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD and other retinal degenerative conditions based on these phagocytosis-related and/or AMD-related genes. Also provided are animal models useful for testing therapeutic compounds and treatment protocols for AMD, and gene arrays including polymorphic variants of phagocytosis-related and/or AMD-related genes, useful for genetic screening of nucleic acid samples from subjects to obtain profiles of polymorphic variant sequences in a plurality of genes associated with AMD.

US Patent:

D664687, Jul 31, 2012

Filed:

Jun 17, 2010

Appl. No.:

29/370228

Inventors:

George Inana - Miami FL, US
Margaret Jean McLaren - Miami FL, US

International Classification:

2604

US Classification:

D26 6

US Patent:

20050176662, Aug 11, 2005

Filed:

Feb 9, 2004

Appl. No.:

10/773446

Inventors:

George Inana - Miami FL, US
Margaret McLaren - Miami FL, US

International Classification:

A61K048/00
A61K039/395
A61K031/557

US Classification:

514044000, 424146100, 514573000

Abstract:

The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD and other retinal degenerative conditions based on these phagocytosis-related and/or AMD-related genes. Also provided are animal models useful for testing therapeutic compounds and treatment protocols for AMD, and gene arrays including polymorphic variants of phagocytosis-related and/or AMD-related genes, useful for genetic screening of nucleic acid samples from subjects to obtain profiles of polymorphic variant sequences in a plurality of genes associated with AMD.

US Patent:

20090144839, Jun 4, 2009

Filed:

Oct 25, 2007

Appl. No.:

11/924346

Inventors:

George Inana - Miami FL, US
Margaret McLaren - Miami FL, US

International Classification:

A01K 67/027
A61K 31/7105
A61K 39/395
C07H 21/00
A61K 31/711

US Classification:

800 13, 514 44, 4241581, 4241721, 536 235

Abstract:

The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD and other retinal degenerative conditions based on these phagocytosis-related and/or AMD-related genes. Also provided are animal models useful for testing therapeutic compounds and treatment protocols for AMD, and gene arrays including polymorphic variants of phagocytosis-related and/or AMD-related genes, useful for genetic screening of nucleic acid samples from subjects to obtain profiles of polymorphic variant sequences in a plurality of genes associated with AMD.

US Patent:

20110294081, Dec 1, 2011

Filed:

May 7, 2011

Appl. No.:

13/068247

Inventors:

Margaret Jean McLaren - Miami FL, US
George Inana - Miami FL, US

International Classification:

F23D 3/16
C11C 5/00

US Classification:

431291

Abstract:

The invention provides transforming container candles that, during burning, exhibit striking color-changing and pattern-forming characteristics. A color-changing transforming container candle may comprise at least a first and a second layer, column or core of wax of different colors. During burning of the candle, the colored wax components become liquefied and intermixed, ultimately transforming into a single layer of wax of a final color differing from that of the original wax layers. Color-changing candles configured in particular color combinations and arrangements of wax components are useful for color therapy of the human energy system, including the chakras and meridians. Transforming candles can be “sentimented” with benevolent intentions and energies (such as the desire for healing, world peace, etc.) by a method that includes the practice of mindfulness by a chandler during the production of the candle.

US Patent:

20120240245, Sep 20, 2012

Filed:

Oct 25, 2011

Appl. No.:

13/317675

Inventors:

GEORGE INANA - MIAMI FL, US
MARGARET JEAN MCLAREN - MIAMI FL, US

International Classification:

A61K 39/395
A61P 27/02
A61K 31/7088
A01K 67/027
A61K 31/713
A61K 31/7105

US Classification:

800 9, 4241581, 4241461, 4241351, 514 44 A, 514 44 R

Abstract:

The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD and other retinal degenerative conditions based on these phagocytosis-related and/or AMD-related genes. Also provided are nonhuman transgenic animal models useful for testing therapeutic compounds and treatment protocols for AMD, and gene arrays including polymorphic variants of phagocytosis-related and/or AMD-related genes, useful for genetic screening of nucleic acid samples from subjects to obtain profiles of polymorphic variant sequences in a plurality of genes associated with AMD. Several preferred embodiments of the therapeutic compositions and animal models are based on target genes MT1-MMP and casein kinase 1 epsilon (CK1ε), phagocytosis-related genes found to be over-expressed in human donor eye samples from patients having both wet and dry forms of AMD.