Frederick K Korley

US Patent:

20220347688, Nov 3, 2022

Filed:

Jul 7, 2022

Appl. No.:

17/859400

Inventors:

- Ann Arbor MI, US
Alyse D. Krausz - Ann Arbor MI, US
Sarah Elizabeth Mena - Ann Arbor MI, US
Martin Patrick De Beer - Ann Arbor MI, US
Kevin R. Ward - Superior Township MI, US
Frederick Korley - Ann Arbor MI, US

International Classification:

B01L 3/00
G01N 33/543
G01N 33/68
G01N 21/64
G01N 1/28
G01N 15/14

Abstract:

A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.

US Patent:

20230077876, Mar 16, 2023

Filed:

Nov 8, 2022

Appl. No.:

17/982769

Inventors:

- Baltimore MD, US
Jennifer E. VAN EYK - Baltimore MD, US
Frederick KORLEY - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

G01N 33/68
C12Q 1/6883

Abstract:

The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.

US Patent:

20200116739, Apr 16, 2020

Filed:

Dec 13, 2019

Appl. No.:

16/713425

Inventors:

- Baltimore MD, US
JENNIFER E. VAN EYK - BALTIMORE MD, US
FREDERICK KORLEY - BALTIMORE MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

G01N 33/68
C12Q 1/6883

Abstract:

The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.

US Patent:

20160178643, Jun 23, 2016

Filed:

Jul 17, 2014

Appl. No.:

14/905312

Inventors:

- Baltimore MD, US
Jennifer E. Van Eyk - Los Angeles CA, US
Frederick Korley - Fulton MD, US

International Classification:

G01N 33/68

Abstract:

The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.