Francoise J Debart from Carlsbad, CA

Backbone Modified Oligonucleotide Analogues
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US Patent:

6900301, May 31, 2005
Filed:

May 22, 2002
Appl. No.:

10/153320
Inventors:

Phillip Dan Cook - Carlsbad CA, US
Yogesh Shantilal Sanghvi - San Marcos CA, US
Jean Jacques Vasseur - Carlsbad CA, US
Francoise Debart - Carlsbad CA, US
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C07H021/02
C07H021/04
US Classification:

536 231, 435 90, 435 912, 435 915, 435 87, 435 911, 536 2534, 536 253, 536 2531, 536 221, 536 256
Abstract:

Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.

Backbone Modified Oligonucleotide Analogues
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US Patent:

59657219, Oct 12, 1999
Filed:

Dec 11, 1996
Appl. No.:

8/763354
Inventors:

Phillip Dan Cook - Carlsbad CA
Yogesh Shantilal Sanghvi - San Marcos CA
Jean Jacques Vasseur - Carlsbad CA
Francoise Debart - Carlsbad CA
Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C07H 2100
US Classification:

536 231
Abstract:

Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.

Francoise J Debart