Eric E Johansson

US Patent:

57552185, May 26, 1998

Filed:

Nov 27, 1996

Appl. No.:

8/758042

Inventors:

Eric T. Johansson - Dublin CA
Carl Ritson - San Jose CA
Reid M. Rubsamen - Berkeley CA

Assignee:

Aradigm Corporation - Hayward CA

International Classification:

A61M 1100

US Classification:

12820014

Abstract:

A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identification code, and permits the canister to be manually depressed to release a dose, e. g. , a metered dose, when out of the durable body. The durable body includes an actuator mechanism for engaging an inserted cassette and its canister, and an actuator release mechanism for controlling the actuator mechanism to depress the canister for a selected period of time to release the desired dose of medication and then the release the canister. The actuator mechanism, includes a compression spring for depressing the canister and a torsion spring for reloading the compression spring. The torsion spring is reloaded by rotating the cassette from an open position for delivering aerosol to a closed position.

US Patent:

57352631, Apr 7, 1998

Filed:

Apr 15, 1996

Appl. No.:

8/632779

Inventors:

Reid M. Rubsamen - Berkeley CA
Lester John Lloyd - Orinda CA
Eric T. Johansson - Dublin CA

Assignee:

Aradigm Corporation - Hayward CA

International Classification:

A61M 1100

US Classification:

12820014

Abstract:

A method of controlling access to a drug in an aerosol drug delivery device by an electronic lock and key means is disclosed. Access is limited to the intended user by providing the intended user with a uniquely coded, machine readable key means that matches the unique code of the lock means. Contacting matching lock and key means signals a controlling means to allow use of the device. Specifically, the method is applied to a method of pain control provided by the intrapulmonary delivery of a pharmaceutically active pain relief formulation. The formulation is automatically released from a hand-held, self-contained, portable device comprised of a means for automatically releasing a measured amount of drug into the inspiratory flow path of a patient in response to information obtained from a means for measuring and separately determining inspiratory flow rate and inspiratory volume of a patient. Reproducible dosing is obtained by providing for automatic release in response to a separately measured inspiratory rate and inspiratory volume. To obtain repeatability in dosing the narcotic formulation is repeatedly released at the same measured (1) inspiratory flow rate and (2) inspiratory volume.

US Patent:

53612825, Nov 1, 1994

Filed:

May 13, 1993

Appl. No.:

8/060669

Inventors:

Ronald B. Adamson - Fremont CA
Donald C. Bartosik - Wilmington NC
Eric B. Johansson - Wrightsville Beach NC
Cedric D. Williams - Wilmington NC

Assignee:

General Electric Company - San Jose CA

International Classification:

G21C 332

US Classification:

376443

Abstract:

A method of manufacturing fuel channels made of zirconium-based alloy by combining heat treatment, warm forming and thermal sizing. Fuel channel strip material is heated to a temperature which initiates the transformation from a hexagonal close-packed to a body-centered cubic crystallographic phase and then quenched at a rate which initiates transformation to a hexagonal close-packed crystallographic phase having a texture factor f. sub. L =0. 28-0. 38. The heat-treated strips are formed into fuel channel components by bending at an elevated temperature sufficient to increase the ductility of the strip material. After the fuel channel components are welded together, the fuel channel is annealed by thermal sizing.

US Patent:

56221622, Apr 22, 1997

Filed:

Feb 16, 1995

Appl. No.:

8/389256

Inventors:

Eric T. Johansson - Dublin CA
Carl Ritson - San Jose CA
Reid M. Rubsamen - Berkeley CA

Assignee:

Aradigm Corporation - Hayward CA

International Classification:

A61M 1100

US Classification:

12820014

Abstract:

A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identification code, and permits the canister to be manually depressed to release a dose, e. g. , a metered dose, when out of the durable body. The durable body includes an actuator mechanism for engaging an inserted cassette and its canister, and an actuator release mechanism for controlling the actuator mechanism to depress the canister for a selected period of time to release the desired dose of medication and then the release the canister. The actuator mechanism, includes a compression spring for depressing the canister and a torsion spring for reloading the compression spring. The torsion spring is reloaded by rotating the cassette from an open position for delivering aerosol to a closed position.

US Patent:

52315916, Jul 27, 1993

Filed:

Jul 5, 1991

Appl. No.:

7/726430

Inventors:

Ross F. Flewelling - Oakland CA
Eric T. Johansson - Dublin CA
Lucille A. Ferus - Oakland CA
John A. Culver - San Francisco CA
Keith H. Breton - San Ramon CA

Assignee:

Nellcor Incorporated - Hayward CA

International Classification:

G01N 2135
G06F 1542

US Classification:

364497

Abstract:

An agent gas analyzer that will determine the types and measure simultaneously the concentrations of a plurality of agent gases in a respiratory gas stream of an anesthetized patient, with the analyzer self-determining the agent gas types and concentrations each time gas measurements are made.

US Patent:

53053591, Apr 19, 1994

Filed:

May 13, 1993

Appl. No.:

8/060668

Inventors:

Ronald B. Adamson - Fremont CA
Donald C. Bartosik - Wilmington NC
Eric B. Johansson - Wrightsville Beach NC
Cedric D. Williams - Wilmington NC

Assignee:

General Electric Company - San Jose CA

International Classification:

G21C 2100

US Classification:

376260

Abstract:

A method of manufacturing components made of zirconium-based alloy by combining heat treatment with thermal sizing. The heat treatment includes heating the component to a temperature which initiates the transformation from a hexagonal close-packed crystallographic phase of uniform texture to a body-centered cubic crystallographic phase and then quenching to a quench temperature at a rate which initiates transformation to a hexagonal close-packed crystallographic phase having a texture factor f. sub. L =0. 28-0. 38. The thermal sizing includes heating the component to a temperature less than the quench temperature, but sufficient to anneal the component, and then cooling. Preferably, the thermal sizing is performed twice: before and after the heat treatment.

US Patent:

53927680, Feb 28, 1995

Filed:

Jan 29, 1993

Appl. No.:

8/011351

Inventors:

Eric T. Johansson - Dublin CA
Carl Ritson - San Jose CA
Reid M. Rubsamen - Berkeley CA

Assignee:

Aradigm - Hayward CA

International Classification:

A61M 1100

US Classification:

12820014

Abstract:

A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identification code, and permits the canister to be manually depressed to release a dose, e. g. , a metered dose, when out of the durable body. The durable body includes an actuator mechanism for engaging an inserted cassette and its canister, and an actuator release mechanism for controlling the actuator mechanism to depress the canister for a selected period of time to release the desired dose of medication and then the release the canister. The actuator mechanism, includes a compression spring for depressing the canister and a torsion spring for reloading the compression spring. The torsion spring is reloaded by rotating the cassette from an open position for delivering aerosol to a closed position.

US Patent:

57432520, Apr 28, 1998

Filed:

Nov 27, 1996

Appl. No.:

8/756409

Inventors:

Reid M. Rubsamen - Berkeley CA
Eric T. Johansson - Dublin CA

Assignee:

Aradigm Corporation - Hayward CA

International Classification:

A61M 1100

US Classification:

12820014

Abstract:

A method for releasing a controlled amount of aerosol medication is disclosed. The method of the invention is preferably used in connection with a portable, battery-powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient. The inhalation breath flow of the user of the apparatus is monitored and the inhalation flow rate is measured, and inhalation volume is determined as a function of the measured flow rate. The measured flow rate is compared to predetermined minimum and maximum flow rate thresholds, and the determined flow volume is compared to predetermined minimum and maximum flow volume thresholds. When both the measured flow rate and the measured flow volume are between their respective the minimum and maximum thresholds, a signal is provided to release a controlled amount of aerosol.