Edgar R Wood

Address:

3101 Belspring Ln, Raleigh, NC 27612

VIN:

5FNYF18587B014778

Make:

HONDA

Model:

PILOT

Year:

2007

US Patent:

20030225090, Dec 4, 2003

Filed:

Feb 27, 2003

Appl. No.:

10/362739

Inventors:

Philip Harris - Durham NC, US
Robert McNutt - Durham NC, US
Lee Kuyper - Durham NC, US
Karen Lackey - Durham NC, US
Michael Peel - Durham NC, US
Edgar Wood - Durham NC, US

International Classification:

A61K031/53
A61K031/454
A61K031/4196
A61K031/405
C 07D 4 3/02
C07D487/02

US Classification:

514/243000, 514/323000, 514/381000, 514/418000, 544/184000, 546/201000, 548/266400, 548/484000

Abstract:

The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

US Patent:

20040198766, Oct 7, 2004

Filed:

Mar 25, 2004

Appl. No.:

10/490831

Inventors:

Karen Lackey - Durham NC, US
Edgar Wood - Durham NC, US

International Classification:

C07D471/02
A61K031/4745

US Classification:

514/300000, 546/113000

Abstract:

The present invention is related to aza-oxindole derivatives formula (I), wherein X is N and Z is CHo; X is CH and Z is N, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

US Patent:

20050228025, Oct 13, 2005

Filed:

Jun 9, 2005

Appl. No.:

11/148635

Inventors:

Scott Dickerson - Durham NC, US
Robert Hunter - Durham NC, US
Lee Kuyper - Durham NC, US
Karen Lackey - Durham NC, US
Michael Luzzio - Noank CT, US
Edgar Wood - Durham NC, US

International Classification:

A61K031/4439
A61K031/433
A61K031/404
C07D417/02
C07D043/02

US Classification:

514337000, 514362000, 514418000, 546277700, 548130000, 548484000

Abstract:

The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

US Patent:

20050282810, Dec 22, 2005

Filed:

Aug 3, 2005

Appl. No.:

11/196597

Inventors:

Philip Harris - Durham NC, US
Robert Hunter - Durham NC, US
Lee Kuyper - Durham NC, US
Karen Lackey - Durham NC, US
Robert McNutt - Durham NC, US
Michael Peel - Durham NC, US
Edgar Wood - Durham NC, US

International Classification:

A61K031/53
A61K031/454
A61K031/4245
A61K031/4196
A61K031/404

US Classification:

514242000, 514323000, 514381000, 514364000, 514418000

Abstract:

The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

US Patent:

20060128745, Jun 15, 2006

Filed:

Jan 20, 2006

Appl. No.:

11/336010

Inventors:

Karen Lackey - Durham NC, US
Edgar Wood - Durham NC, US

International Classification:

A61K 31/4745
C07D 471/02

US Classification:

514300000, 546113000

Abstract:

The present invention is related to aza-oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

US Patent:

20070148261, Jun 28, 2007

Filed:

Oct 11, 2006

Appl. No.:

11/548413

Inventors:

Karen LACKEY - Durham NC, US
Robert Mullen - Durham NC, US
Neil Spector - Chapel Hill NC, US
Edgar Wood - Durham NC, US
Wenie Xia - Durham NC, US

International Classification:

A61K 33/24
A61K 31/517
A61K 31/282

US Classification:

424649000, 514266240, 514492000

Abstract:

A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.