An apparatus for inoculating a sample to or withdrawing a sample from a vessel or conduit includes a body with an internal collection chamber formed therein. A valve operating rod is movable to open and close an orifice in the collection chamber. The mechanism used to reciprocate the valve operating rod to open and close the orifice can be either manual and automatic. Furthermore, a drain passage having an opening in communication with the collection chamber is located adjacent to or below the opening of the orifice. An inlet passage having an opening in communication with the collection chamber is located above the opening of the drain passage. A seal is formed between the movable valve operating rod and the body, thereby separating and isolating certain mechanical parts of the valve from certain other process-contact parts of the valve. The seal is formed by one of seal glands, o-rings, flexible diaphragms or other device. Finally, a insulating jacket is provided to insulate the inside chambers of the valve from its surroundings.
A method and apparatus for capturing a sample of flowable material from a closed system inside a receptacle without exposing the sample to the ambient environment. The apparatus includes a housing having an opening at one end for receiving a receptacle and stopper. An end cap is removably mounted to the housing for opening and closing the opening. An inlet is provided in the housing for feeding a cleaning or sterilizing agent or the flowable material to be sampled into an interior of the housing. A clasp is provided to manipulate the receptacle to separate the receptacle and the stopper while the stopper and receptacle are inside of the housing. Once the receptacle and the stopper are separated, the flowable material is fed into the receptacle through the inlet. The clasp is then manipulated to reattach the receptacle and the stopper in order to capture the flowable material. The apparatus is particularly useful in the pharmaceutical and biotechnology industries as well as the fine chemical, food and beverage industries where accurate, uncontaminated samples of materials from a closed system are desired without contaminating the sample of material or the closed system.
A valve for sampling a process from a tank or conduit includes an internal cavity in communication with at least one inlet and an outlet. A valve actuating rod includes a sealing tip attached to one end thereof The valve actuating rod is movable to open and close the inlet to the internal cavity. Furthermore, a seal is provided to isolate the valve actuating rod and the outside environment from the process. The seal is formed on the process side of the bottom wall of the internal cavity in order to ensure that the process material, cleaning material, steam, etc. drains completely out of the internal cavity of the valve.
An apparatus for inoculating a sample to or withdrawing a sample from a vessel or conduit includes a body with an internal collection chamber formed therein. A valve operating rod is movable to open and close an orifice in the collection chamber. The mechanism used to reciprocate the valve operating rod to open and close the orifice can be either manual and automatic. Furthermore, a drain passage having an opening in communication with the collection chamber is located adjacent to or below the opening of the orifice. An inlet passage having an opening in communication with the collection chamber is located above the opening of the drain passage. A seal is formed between the movable valve operating rod and the body, thereby separating and isolating certain mechanical parts of the valve from certain other process-contact parts of the valve. The seal is formed by one of seal glands, o-rings, flexible diaphragms or other device. Finally, a insulating jacket is provided to insulate the inside chambers of the valve from its surroundings.
A valve for sampling a process from a tank or conduit includes an internal cavity in communication with at least one inlet and an outlet. A valve actuating rod includes a sealing tip attached to one end thereof. The valve actuating rod is movable to open and close the inlet to the internal cavity. Furthermore, a seal is provided to isolate the valve actuating rod and the outside environment from the process. The seal is formed on the process side of the bottom wall of the internal cavity in order to ensure that the process material, cleaning material, steam, etc. drains completely out of the internal cavity of the valve.
A valve body for a valve includes a body having an internal cavity formed therein. An inlet passage and an outlet passage are formed in the body. The inlet passage has an inlet opening in communication with the internal cavity, and the outlet passage has an outlet opening in communication with the internal cavity. A circumferential sealing surface is formed on a wall of the internal cavity. The circumferential sealing surface extends between the inlet opening and the outlet opening and circumferentially around the internal cavity. Furthermore, a bottom line extending through the inlet passage, the internal cavity and the outlet passage forms a coplanar surface to allow for free-drainage of the body.
An apparatus for inoculating a sample to or withdrawing a sample from a vessel or conduit includes a body with an internal sample cavity, a valve operating rod movable to open and close an orifice to the sample cavity and a coupler to attach the body to a port of the vessel or conduit. A portion of the sample cavity is formed by an endcap which includes the orifice. The sample cavity is thermally and/or electrically insulated from the vessel or conduit. This insulation can arise from an empty or filled space between an inner wall and outer wall of the valve. Otherwise, insulating material can be used in forming the valve. The valve can be mountable on the vessel or conduit such that a positive drain angle is maintained regardless of whether the ferrule to the vessel or conduit is inclined upwardly, downwardly or is horizontal.
System For Multiple Sterile Sample Collection And Isolation
This device is directed at filling multiple receptacles without losing integrity of the system. It is also directed at receiving a (sealed) container of receptacles (opened or stopper/closed), opening an access into the sealed container, retrieving receptacles, filling those receptacles, stoppering the receptacles after filling and ejecting the receptacles, either directly into the outside environment or into a closable sack or container, in the latter case while maintaining the integrity of the environment within the device and, if desirable, the sack or closed container.