Donghua D Dai from Superior, CO, age 46

Us Patents

Substituted Pyrazolo[3,4-D]Pyrimidine Compounds As Ret Kinase Inhibitors
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US Patent:

20200399279, Dec 24, 2020
Filed:

Jan 18, 2019
Appl. No.:

16/961973
Inventors:

- Boulder CO, US
Donghua DAI - Boulder CO, US
Julia HAAS - Boulder CO, US
Yutong JIANG - Boulder CO, US
Gabrielle R. KOLAKOWSKI - Longmont CO, US
Andrew T. METCALF - Boulder CO, US
David A. MORENO - Boulder CO, US
Brett PRIGARO - Boulder CO, US
Li REN - Boulder CO, US
International Classification:

C07D 487/04
Abstract:

Provided herein are compounds of the Formula I: and tautomers and pharmaceutically acceptable salts and solvates thereof, wherein Rand Rhave the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Substituted Pyrazolyl[4,3-C]Pyridine Compounds As Ret Kinase Inhibitors
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US Patent:

20200339579, Oct 29, 2020
Filed:

Jan 18, 2019
Appl. No.:

16/962305
Inventors:

- Boulder CO, US
LI REN - Boulder CO, US
Ginelle A. RAMANN - Boulder CO, US
David A. MORENO - Boulder CO, US
Andrew T. METCALF - Boulder CO, US
Elizabeth A. MCFADDIN - Boulder CO, US
Gabrielle R. KOLAKOWSKI - Longmont CO, US
James F. BLAKE - Boulder CO, US
Donghua DAI - Boulder CO, US
Julia HAAS - Boulder CO, US
Yutong JIANG - Boulder CO, US
Dean KAHN - Boulder CO, US
International Classification:

C07D 471/04
C07F 9/6561
Abstract:

Provided herein are compounds of the Formula I: and tautomers and pharmaceutically acceptable salts and solvates thereof, wherein R, Rand Rhave the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Substituted Pyrrolo[2,3-D]Pyrimidines Compounds As Ret Kinase Inhibitors
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US Patent:

20200339589, Oct 29, 2020
Filed:

Jan 18, 2019
Appl. No.:

16/962345
Inventors:

- Boulder CO, US
Donghua DAI - Boulder CO, US
Julia HAAS - Boulder CO, US
Yutong JIANG - Boulder CO, US
Gabrielle R. KOLAKOWSKI - Longmont CO, US
Elizabeth A. MCFADDIN - Nederland CO, US
Megan L. MCKENNEY - Boulder CO, US
Andrew T. METCALF - Boulder CO, US
David A. MORENO - Boulder CO, US
Brett PRIGARO - Boulder CO, US
Ginelle A. RAMANN - Boulder CO, US
Li REN - Boulder CO, US
International Classification:

C07D 487/04
Abstract:

Provided herein are compounds of the Formula I: [INSERT FORMULA I] and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and Ry have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Resumes

Principal Scientist

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Location:

1001 Sheldon Dr, Cary, NC 27513

Industry:

Pharmaceuticals

Work:

Array Biopharma Inc.
Senior Research Scientist
Array Biopharma Inc. Aug 2016 - Dec 2017
Medicinal Chemist
Civentichem Jan 2008 - Jun 2016
Senior Research Scientist
Duke University Jul 2006 - Dec 2007
Postdoctoral Fellow
Wayne State University Jul 2005 - Jul 2006
Postdoctoral Fellow

Education:

Duke University 2006 - 2007
Wayne State University 2005 - 2006
Howard University 2000 - 2005
Doctorates, Doctor of Philosophy, Organic Chemistry Shanghai Jiao Tong University 1995 - 1999
Bachelors, Bachelor of Science, Chemistry

Skills:

Organic Synthesis
Drug Design
Hplc
Medicinal Chemistry
Organic Chemistry
Chemistry
Nmr
Lc Ms
Mass Spectrometry
Purification
R&D
Drug Discovery
Gc Ms
Gmp
Process Development
Process Simulation
Ir
High Performance Liquid Chromatography
Nuclear Magnetic Resonance

Languages:

English
Mandarin

Donghua Dai Cary, NC

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Work:

CiVentiChem, LLC

2010 to 2000
Senior Research Scientist Duke University
Durham, NC
2006 to 2007
Postdoctoral Fellow Wayne State University
Detroit, MI
2005 to 2006
Postdoctoral Fellow Howard University
Washington, DC
2000 to 2005 Howard University

2000 to 2005
Graduate Teaching Assistant Shanghai ZhongYuan Co., Ltd

1999 to 2000
Sales representative

Education:

Howard University
Washington, DC
2000 to 2005
PhD in Chemistry Shanghai Jiaotong University
1995 to 1999
B.S. in Polymer Science and Engineering