Diane E Nedberge

US Patent:

20070104771, May 10, 2007

Filed:

Sep 22, 2006

Appl. No.:

11/525696

Inventors:

Jay Audett - Mountain View CA, US
Eli Goldman - San Francisco CA, US
Delphine Imbert - Cupertino CA, US
Diane Nedberge - Los Altos CA, US
Jianye Wen - Palo Alto CA, US
Allison Luciano - Lebanon NJ, US
Eric Silverberg - Summit NJ, US
Paul Foreman - Somerville NJ, US
Johan Geerke - Los Altos CA, US

International Classification:

A61K 9/70
A61K 31/55

US Classification:

424449000, 514214010

Abstract:

A transdermal galantamine delivery system to an individual. The system has a high galantamine loading with suitable permeation enhancers to effect therapeutic flux rate. Acrylate polymeric reservoir with the high galantamine and permeation enhancers dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties for multiple-day delivery.

US Patent:

20070134310, Jun 14, 2007

Filed:

Sep 22, 2006

Appl. No.:

11/525976

Inventors:

Diane Nedberge - Los Altos CA, US
Robert Gale - Los Altos CA, US
Nieves Crisologo - Sunnyvale CA, US
Jianye Wen - Palo Alto CA, US
Delphine Imbert - Cupertino CA, US
Allison Luciano - Lebanon NJ, US
Eric Silverberg - Summit NJ, US
Paul Foreman - Somerville NJ, US
Johan Geerke - Los Altos CA, US

International Classification:

A61K 9/70
A61K 31/519

US Classification:

424449000, 514259410

Abstract:

A system for transdermal delivery of risperidone to an individual. The system has a high risperidone loading with suitable permeation enhancers to effect therapeutic flux rate. Acrylate polymeric reservoir with the high risperidone and permeation enhancers dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.

US Patent:

47465158, May 24, 1988

Filed:

Feb 26, 1987

Appl. No.:

7/019470

Inventors:

Yu-Ling Cheng - Cupertino CA
Diane E. Nedberge - Los Altos CA
Edna Sugihara - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61F 1300

US Classification:

424449

Abstract:

A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with glycerol monolaurate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monolaurate employ matrix containing drug at a concentration above saturation.

US Patent:

56415044, Jun 24, 1997

Filed:

Oct 21, 1993

Appl. No.:

8/162026

Inventors:

Eun Soo Lee - Redwood City CA
Diane E. Nedberge - Los Altos CA
Su Il Yum - Los Altos CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61L 1516

US Classification:

424447

Abstract:

The present invention provides compositions and systems for the transdermal administration of a drug together with glycerol monolinoleate as a permeation enhancer. An example of a delivery system of the invention is a system (20) having a drug reservoir (22) containing together a drug to be delivered and glycerol monolinoleate permeation enhancer. Reservoir is sandwiched between a backing layer (24) and an in-line contact adhesive layer (28).

US Patent:

60078375, Dec 28, 1999

Filed:

Feb 3, 1999

Appl. No.:

9/243890

Inventors:

David J. Enscore - Sudbury MA
Patricia S. Campbell - Palo Alto CA
Diane Nedberge - Los Altos CA
Richard D. Frame - San Diego CA

Assignee:

Alza Corporation - Mt. View CA

International Classification:

A61K 970

US Classification:

424449

Abstract:

An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular application in the manufacture of transdermal drug delivery devices including a drug reservoir comprising drug in excess of saturation.

US Patent:

61745456, Jan 16, 2001

Filed:

Feb 3, 1999

Appl. No.:

9/243873

Inventors:

David J. Enscore - Sudbury MA
Patricia S. Campbell - Palo Alto CA
Diane Nedberge - Los Altos CA
Richard D. Frame - San Diego CA

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61F 1302

US Classification:

424448

Abstract:

An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular application in the manufacture of transdermal drug delivery devices including a drug reservoir comprising drug in excess of saturation.

US Patent:

6248348, Jun 19, 2001

Filed:

Apr 26, 1999

Appl. No.:

9/300010

Inventors:

Felix A. Landrau - Sarasota FL
Diane E. Nedberge - Los Altos CA
Linda M. Hearney - Saratoga CA

Assignee:

ALZA Corporation - Mountain View CA

International Classification:

A61F 1302
A61F 1300

US Classification:

424448

Abstract:

The present invention comprises a composition comprising a matrix (12) adapted to be placed in drug- and permeation-enhancing mixture-transmitting relation to a selected skin (18) or other body site. The matrix (12) contains sufficient amounts of drug, permeation enhancer(s) and poly-N-vinyl amide to continuously administer to the site, the drug, in a therapeutically effective amount, and the permeation-enhancing mixture, in an amount effective to enhance the permeation of the skin (18) to the drug, the device (10) shows increased transdermal flux as compared to the transdermal flux of the drug from a device (10) containing no poly-N-vinyl amide. Incorporating poly-N-vinyl amide into the transdermal system also improves the adhesion and stability of the system.

US Patent:

51223821, Jun 16, 1992

Filed:

Oct 29, 1990

Appl. No.:

7/605726

Inventors:

Robert M. Gale - Los Altos CA
Diane E. Nedberge - Los Altos CA
Linda E. Atkinson - Portola Valley CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61F 1340

US Classification:

424449

Abstract:

The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with a suitable permeation enhancer.