Dennis G Cheek

US Patent:

20020197253, Dec 26, 2002

Filed:

May 22, 2002

Appl. No.:

10/153153

Inventors:

Dennis Cheek - Cary NC, US
Salvatore Pizzo - Bahama NC, US
Tammy Moser - Chapel Hill NC, US

International Classification:

A61K039/395

US Classification:

424/141100, 424/146100, 514/012000

Abstract:

Compounds, compositions and methods for promoting or inhibiting angiogenesis, and screening methods for identifying compounds are disclosed. The compounds bind to NDPK or angiostatin. When bound to these NDPK, they can function as angiogenesis inhibitors. When bound to angiostatin in a manner that inhibits the ability of angiostatin to bind to NDPK, they can function as angiogenesis promoters. The compounds can be, for example, antibodies, antibody fragments, enzymes, peptides, nucleic acids such as oligonucleotides, or small molecules. The antibodies can be monoclonal, humanized, or polyclonal antibodies. The compounds can be conjugated to or combined with various cytotoxic agents and/or labeled compounds. Methods for promoting angiogenesis can be used to introduce vasculature to areas in a patient that can benefit from such increased vasculature. Methods for inhibiting angiogenesis can be used to treat disorders mediated by angiogenesis, for example, tumors, autoimmune disorders such as rheumatoid arthritis, and the like.