- Tarrytown NY, US Eric Smith - New York NY, US Ka-Man Venus Lai - Seattle WA, US Andrew J. Murphy - Croton-on-Hudson NY, US Gavin Thurston - Briarcliff Manor NY, US Dayong Guo - Overland Park KS, US
International Classification:
A01K 67/027 C07K 14/725 G01N 33/50
Abstract:
Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.
Non-Human Animals Having A Engineered Angptl8 Gene
- Tarrytown NY, US Andrew J. Murphy - Croton-on-Hudson NY, US Jesper Gromada - Scarsdale NY, US Dayong Guo - Overland Park KS, US
International Classification:
A01K 67/027
Abstract:
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin-like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.
- Tarrytown NY, US Eric Smith - New York NY, US Ka-Man Venus Lai - Tarrytown NY, US Andrew J. Murphy - Croton-on-Hudson NY, US Gavin Thurston - Briarcliff Manor NY, US Dayong Guo - Overland Park KS, US
Assignee:
Regeneron Pharmaceuticals, Inc. - Tarrytown NY
International Classification:
A01K 67/027 C07K 14/725
Abstract:
Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.