C. Frank Bennett - Carlsbad CA David S. Grass - Lawrenceville NJ Mark E. Swanson - Princeton Junction NJ
Assignee:
DNX Biotherapeutics - Princeton NJ
International Classification:
C12N 500 C12N 1500 G01N 3348
US Classification:
800 2
Abstract:
The present invention concerns transgenic animals that express an abnormaly high level of phospholipase A. sub. 2 in their serum, liver, lung, kidney and skin. More particularly rats and mice expressing human non-pancreatic, low molecular weight phospholipase A. sub. 2 are disclosed. Although transfected with a normal human gene, the animals develop a variety of pathological signs and produce the enzyme ectopically. The animals of the invention are useful for the testing of compounds to determine whether the compounds possess in vivo activity as phospholipase inhibitors or antagonists suitable for pharmacolgic use.
Youtube
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Episode 2, part 1
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september grass - at the close of every day &...
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News
Poison parsnip causes severe burns, blisters on woman's legs
David Grass of the Vermont Department of Health says the sap in the parsnip has a chemical reaction with the sun that causes accelerated burns. He says people should wear long pants and sleeves while in tall grass.