Costel Chirila

US Patent:

8546098, Oct 1, 2013

Filed:

Apr 27, 2012

Appl. No.:

13/457620

Inventors:

Yun Fu Hu - Chapel Hill NC, US
Costel Chirila - Durham NC, US
Danny Alexander - Cary NC, US
Michael Milburn - Cary NC, US
Matthew W. Mitchell - Durham NC, US
Walter Gall - Chapel Hill NC, US
Kay A. Lawton - Raleigh NC, US

Assignee:

Metabolon, Inc. - Durham NC

International Classification:

C12Q 1/54

US Classification:

435 14

Abstract:

Biomarkers relating to insulin resistance are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance. These biomarkers may be used to monitor the progression or regression of insulin resistance or to monitor the efficacy of insulin resistance treatment. Also provided are suites of small molecule entities as biomarkers for insulin resistance.

US Patent:

20090155826, Jun 18, 2009

Filed:

Jul 17, 2008

Appl. No.:

12/218980

Inventors:

Yun Fu Hu - Chapel Hill NC, US
Costel Chirila - Durham NC, US
Danny Alexander - Cary NC, US
Michael Milburn - Cary NC, US
Matthew W. Mitchell - Durham NC, US
Walter Gall - Chapel Hill NC, US
Kay A. Lawton - Raleigh NC, US

Assignee:

Metabolon, Inc. - Durham NC

International Classification:

C12Q 1/60
C12Q 1/54

US Classification:

435 11, 435 14

Abstract:

Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

US Patent:

20120122981, May 17, 2012

Filed:

Mar 31, 2010

Appl. No.:

13/258780

Inventors:

Yun Fu Hu - Chapel Hill NC, US
Costel Chirila - Durham NC, US
Danny Alexander - Cary NC, US
Michael Milburn - Cary NC, US
Matthew W. Mitchell - Durham NC, US
Walter Gall - Chapel Hill NC, US
Kay A. Lawton - Raleigh NC, US

International Classification:

A61K 31/201
C12Q 1/25
C12Q 1/02
H01J 49/26
A61P 3/10
G01N 30/00
G01R 33/46
G01N 21/35
G01N 33/53
C07C 57/03

US Classification:

514560, 435 792, 435 4, 435 29, 554224, 73 6152, 73 2335, 324307, 356 51, 250282

Abstract:

Biomarkers relating to glucose disposal rate, insulin resistance, and/or insulin resistance-related disorders are provided. Methods based on the same biomarkers are also provided.

US Patent:

20130338031, Dec 19, 2013

Filed:

Aug 14, 2013

Appl. No.:

13/966475

Inventors:

Yun Fu Hu - Chapel Hill NC, US
Costel Chirila - Durham NC, US
Danny Alexander - Cary NC, US
Michael Milburn - Cary NC, US
Matthew W. Mitchell - Durham NC, US
Walter Gall - Chapel Hill NC, US
Kay A. Lawton - Raleigh NC, US

International Classification:

G01N 33/483
G01N 33/50

US Classification:

506 9, 506 12, 436501, 435 792

Abstract:

Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

US Patent:

20160178620, Jun 23, 2016

Filed:

Dec 21, 2015

Appl. No.:

14/975988

Inventors:

- Durham NC, US
Costel CHIRILA - Durham NC, US
Danny ALEXANDER - Cary NC, US
Michael MILBURN - Cary NC, US
Matthew W. MITCHELL - Durham NC, US
Walter GALL - Chapel Hill NC, US
Kay A. LAWTON - Raleigh NC, US

International Classification:

G01N 33/53
G01N 33/483

Abstract:

Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

US Patent:

20150005195, Jan 1, 2015

Filed:

Jul 7, 2014

Appl. No.:

14/324689

Inventors:

Yun Fu HU - Chapel Hill NC, US
Costel Chirila - Durham NC, US
Danny Alexander - Cary NC, US
Michael Milburn - Cary NC, US
Matthew W. Mitchell - Durham NC, US
Walter Gall - Chapel Hill NC, US
Kay A. Lawton - Raleigh NC, US

International Classification:

G01N 33/487

US Classification:

506 12

Abstract:

Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.