Clifton J Blankley

US Patent:

56209819, Apr 15, 1997

Filed:

May 3, 1995

Appl. No.:

8/433294

Inventors:

Clifton J. Blankley - Ann Arbor MI
Diane H. Boschelli - Plymouth MI
Annette M. Doherty - Ann Arbor MI
James M. Hamby - Ann Arbor MI
Sylvester Klutchko - Ann Arbor MI
Robert L. Panek - Canton MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31505
C07D48702

US Classification:

514258

Abstract:

6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.

US Patent:

54896860, Feb 6, 1996

Filed:

Apr 28, 1994

Appl. No.:

8/234759

Inventors:

Clifton J. Blankley - Ann Arbor MI
John C. Hodges - Ann Arbor MI
Sylvester Klutchko - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D21700

US Classification:

546147

Abstract:

This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.

US Patent:

57339139, Mar 31, 1998

Filed:

Nov 6, 1995

Appl. No.:

8/539410

Inventors:

Clifton John Blankley - Ann Arbor MI
Annette Marian Doherty - Ann Arbor MI
James Marino Hamby - Ann Arbor MI
Robert Lee Panek - Canton MI
Mel Conrad Schroeder - Dexter MI
Howard Daniel Hollis Showalter - Ann Arbor MI
Cleo Connolly - Livonia MI

International Classification:

C07D47104
A61K 31505

US Classification:

514258

Abstract:

6-Aryl pyrido�2,3-d!pyrimidines and naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.

US Patent:

59523425, Sep 14, 1999

Filed:

Mar 18, 1998

Appl. No.:

9/040792

Inventors:

Clifton John Blankley - Ann Arbor MI
Annette Marian Doherty - Ann Arbor MI
James Marino Hamby - Ann Arbor MI
Robert Lee Panek - Canton MI
Mel Conrad Schroeder - Dexter MI
Howard Daniel Hollis Showalter - Ann Arbor MI
Cleo Connolly - Livonia MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D47104
A61K 3144

US Classification:

514300

Abstract:

6-Aryl naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.

US Patent:

59454210, Aug 31, 1999

Filed:

Aug 11, 1997

Appl. No.:

8/909171

Inventors:

Thomas Richard Belliotti - Saline MI
Clifton John Blankley - Ann Arbor MI
Suzanne Ross Kesten - Ann Arbor MI
Lawrence David Wise - Ann Arbor MI
David Juergen Wustrow - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31495
A61K 3147
C07D40106
C07D40306

US Classification:

514253

Abstract:

This invention relates to compounds that are antagonists of dopamine D4 receptors, to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors, and to pharmaceutically acceptable compositions that contain a dopamine D4 receptor antagonist.

US Patent:

42711649, Jun 2, 1981

Filed:

Mar 11, 1980

Appl. No.:

6/123781

Inventors:

Clifton J. Blankley - Ann Arbor MI
Lawrence R. Bennett - Chelsea MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D47104
A61K 31495

US Classification:

424251

Abstract:

6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives and their pharmaceutically acceptable acid addition salts are useful in the treatment of hypertension.

US Patent:

55256147, Jun 11, 1996

Filed:

Jul 31, 1995

Appl. No.:

8/509473

Inventors:

Clifton J. Blankley - Ann Arbor MI
John C. Hodges - Ann Arbor MI
Sylvester Klutchko - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3147

US Classification:

514307

Abstract:

This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.

US Patent:

53507576, Sep 27, 1994

Filed:

Jun 11, 1993

Appl. No.:

8/075973

Inventors:

Clifton J. Blankley - Ann Arbor MI
John C. Hodges - Ann Arbor MI
Sylvester Klutchko - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3147

US Classification:

514307

Abstract:

This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.