Cleo M Salisbury

US Patent:

20170239355, Aug 24, 2017

Filed:

Dec 28, 2016

Appl. No.:

15/393143

Inventors:

- South San Francisco CA, US
Danielle LEISKE - South San Francisco CA, US
Lydia HAMBURG - South San Francisco CA, US
Cleo SALISBURY - South San Francisco CA, US

International Classification:

A61K 47/22
G01N 33/68
B01D 15/32
G06F 19/24
G01N 30/88
C07K 16/24
G01N 33/15

Abstract:

The invention provides methods and formulations comprising a protein comprising solvent accessible amino acid residues susceptible to oxidation wherein N-acetyl tryptophan (NAT) is used to prevent oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. Methods to measure degradation of NAT in protein formulations are also provided.