Chad A Lieber

US Patent:

8123745, Feb 28, 2012

Filed:

Jun 29, 2007

Appl. No.:

11/824038

Inventors:

Christopher Beeckler - Brea CA, US
Chad Allen Lieber - Chino Hills CA, US
Shiva Sharareh - Laguna Niguel CA, US

Assignee:

Biosense Webster, Inc. - Diamond Bar CA

International Classification:

A61B 18/14

US Classification:

606 41, 600374

Abstract:

A catheter enables real-time light measurements, for example, without limitation, diffuse reflectance, fluorescence, etc. , from biological materials, such as tissue (including blood), while performing RF ablation. The catheter tip design isolates illumination and collection paths such that light exits the catheter tip and travels through the tissue of interest (e. g. , cardiac tissue or blood) before returning to the catheter tip. Such a design advantageously avoids saturation of the optical detector, and ensures diffusion of the illumination light within the medium of interest. The catheter has a catheter body and a tip electrode. The tip electrode has an exterior shell, an inner layer of diffuse material and a hollow cavity, wherein the inner layer is configured to transmit light outside the tip electrode to a tissue via a set of illumination openings in the shell wall and the hollow cavity is configured to receive light from the tissue via a set of collection openings in the shell wall and the inner layer. An inner surface of the inner layer has a reflective coating to isolate light injected into the inner layer from light collected in the hollow cavity. There are a first optical waveguide extending between the catheter body and the tip electrode to inject light into the inner layer and illuminate the tissue, and a second optical waveguide extending between the catheter body and the tip electrode to collect the recaptured light in the hollow cavity.

US Patent:

8147484, Apr 3, 2012

Filed:

Oct 23, 2006

Appl. No.:

11/552075

Inventors:

Chad Allen Lieber - Chino Hills CA, US
Ariel Garcia - Duarte CA, US
Shiva Sharareh - Laguna Niguel CA, US

Assignee:

Biosense Webster, Inc. - Diamond Bar CA

International Classification:

A61B 18/04

US Classification:

606 32, 606 2, 606 34, 600475, 600477

Abstract:

A system and method that enable real-time optical measurements of tissue reflection spectral characteristics while performing ablation, involves the radiation of tissue and recapturing of light from the tissue to monitor changes in the reflected optical intensity as an indicator of steam formation in the tissue for prevention of steam pop. The system includes a catheter adapted to collect light reflected from tissue undergoing ablation, a detection component that identifies and separates constituent wavelengths of collected light, a quantification apparatus for generating measured light intensity data for the collected light, and a processor that analyses the measured light intensity data in relation to time. The system may include a graphical display and/or an audio output (e. g. , speaker) that provide visual and/or audio alarm when the system infers formation of a steam pocket in the tissue.

US Patent:

8500730, Aug 6, 2013

Filed:

Nov 16, 2007

Appl. No.:

11/941884

Inventors:

James K. Lee - San Mateo CA, US
Chad Allen Lieber - Chino Hills CA, US
Michael Olen Zirkle - Fullerton CA, US

Assignee:

Biosense Webster, Inc. - Diamond Bar CA

International Classification:

A61B 18/14

US Classification:

606 41

Abstract:

A catheter enables real-time light measurements from tissue while performing RF ablation. The tip design isolates illumination and collection paths such that light exits the tip and travels through the tissue before returning to the tip. The catheter has a tip electrode having an exterior shell, an inner layer and a hollow cavity. The inner layer is configured to transmit light outside the tip electrode, and the hollow cavity is configured to receive light. An inner surface of the inner layer has an opaque coating to isolate light injected into the inner layer from light collected in the hollow cavity. A first optical waveguide extends between the catheter body and tip electrode to inject light into the inner layer and illuminate the tissue, and a second optical waveguide extends between the catheter body and tip electrode to collect the recaptured light in the hollow cavity.

US Patent:

8628520, Jan 14, 2014

Filed:

May 2, 2006

Appl. No.:

11/417092

Inventors:

Shiva Sharareh - Laguna Niguel CA, US
Chad Allen Lieber - Chino Hills CA, US
Jeffrey William Schultz - La Verne CA, US

Assignee:

Biosense Webster, Inc. - Diamond Bar CA

International Classification:

A61B 18/18

US Classification:

606 17, 606 13, 606 16

Abstract:

A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush the opening with fluid. The light energy returning to the chamber from the tissue conveys a tissue parameter, including without limitation, lesion formation, depth of penetration of lesion, cross-sectional area of lesion, formation of char during ablation, recognition of char during ablation, recognition of char from non-charred tissue, formation of coagulum around the ablation site, differentiation of coagulated from non-coagulated blood, differentiation of ablated from healthy tissue, tissue proximity, and recognition of steam formation in the tissue for prevention of steam pop.

US Patent:

8641706, Feb 4, 2014

Filed:

Mar 29, 2012

Appl. No.:

13/434554

Inventors:

Chad Allen Lieber - Chino Hills CA, US
Ariel Garcia - Duarte CA, US
Shiva Sharareh - Laguna Niguel CA, US

Assignee:

Biosense Webster, Inc. - Diamond Bar CA

International Classification:

A61B 18/12

US Classification:

606 34, 606 32

Abstract:

A system for measuring real-time tissue reflection spectral characteristics during ablation includes a catheter for collecting light reflected from tissue undergoing ablation, a detection component for separating constituent wavelengths of the collected light, a quantification apparatus for generating measured light intensity data of the collected light, and a processor for analyzing the data in relation to time. A method for monitoring formation of steam pop during ablation includes delivering light to tissue, delivering ablative energy to the tissue, measuring the reflectance spectral intensity of the tissue, and observing whether the measured reflectance spectral intensity (MRSI) initially increases in a specified time period followed by a decrease at a specified rate. If the MRSI does not decrease, delivery of ablation energy continues. If the MRSI decreases within the specified time at the specified rate, formation of a steam pocket is inferred and delivery of ablative energy is decreased or discontinued.

US Patent:

20080154257, Jun 26, 2008

Filed:

Dec 22, 2006

Appl. No.:

11/644312

Inventors:

Shiva Sharareh - Laguna Nigel CA, US
Chad A. Lieber - Chino Hills CA, US

International Classification:

A61B 18/18

US Classification:

606 41

Abstract:

A system and method for opto-acoustic tissue and lesion assessment in real time on one or more of the following tissue characteristics: tissue thickness, lesion progression, lesion width, steam pop, and char formation, system includes an ablation element, laser delivery means, and an acoustic sensor. The invention involves irradiating tissue undergoing ablation treatment to create acoustic waves that have a temporal profile which can be recorded and analyzed by acoustic sampling hardware for reconstructing a cross-sectional aspect of the irradiated tissue. The ablation element (e.g., RF ablation), laser delivery means and acoustic sensor are configured to interact with a tissue surface from a common orientation; that is, these components are each generally facing the tissue surface such that the direction of irradiation and the direction of acoustic detection are generally opposite to each other, where the stress waves induced by the laser-induced heating of the tissue below the surface are reflected back to the tissue surface.

US Patent:

20090005771, Jan 1, 2009

Filed:

Jun 28, 2007

Appl. No.:

11/770604

Inventors:

Chad Allen Lieber - Chino Hills CA, US
Shiva Sharareh - Laguna Niguel CA, US

International Classification:

A61B 18/14
A61B 5/01

US Classification:

606 34, 600549

Abstract:

A system for opto-pyrometric tissue temperature monitoring in real time. The system is adapted for cardiac ablation and tissue temperature measurement, having a catheter having a tip electrode adapted for RF ablation of cardiac tissue and an optical collector whose distal end is received in an opening formed in the tip electrode to detect black body radiation from the cardiac tissue. The system includes an optical detection system in communication with the optical collector, the optical processing system processing signals representative of a wavelength of at least a portion of the black body radiation to determine a tissue temperature. The incorporation of an optical collector within a catheter tip permits real time monitoring of tissue temperature during ablation and lesion formation to prevent critical thresholds in temperature associated with events that can damage tissue, including steam pop, thrombus, char, etc.

US Patent:

20090253990, Oct 8, 2009

Filed:

Dec 5, 2008

Appl. No.:

12/329311

Inventors:

Chad Allen Lieber - Chino Hills CA, US
Diane Jean Nugent - San Juan Capistrano CA, US
Amit Soni - Irvine CA, US

Assignee:

Children's Hospital of Orange County - Orange CA

International Classification:

A61B 6/00

US Classification:

600476

Abstract:

Non-invasive systems and methods to distinguish between blood and synovial fluid in patients are described. In one embodiment, the system comprises a patient interface system that can be placed over a swollen joint. A region of the swollen joint is illuminated with radiation. The scattered or transmitted radiation from the region of effusion is collected by a collection system and detected by a radiation detector. The information from the detector is analyzed by an analytic processing system to diagnose the cause of the joint effusion.