Bruce D Compton

from Marshfield, MA

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Connected to:

Bruce Compton Phones & Addresses

Marshfield, MA
Quincy, MA

Work

Company:

Umass lowell biomanufacturing center
Feb 2009
Position:

Research professor

Education

School / High School:

Univ. Utah- Salt Lake City, UT
1980
Specialities:

Doctoral

Resumes

Bruce Compton

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Bruce Compton

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Bruce Compton

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Bruce Compton

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Bruce Compton

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Principal Cmc Regulatory Consultant At Compton Associates

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Location:

Greater Boston Area

Industry:

Biotechnology

Bruce Compton Lowell, MA

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Work:

UMass Lowell Biomanufacturing Center

Feb 2009 to 2000
Research Professor The Scripps Research Institute

2001 to 2000
Visiting Scientist, Core Mass Spectrometry Facility Aphios Corporation
Woburn, MA
Jan 2012 to Jan 2013
Vice President of Drug Development Northeastern Univ. Barnett Inst. and the Center for Adv. Reg. Analysis (CARA)
Boston, MA
2010 to 2012
Research Associate Professor and Director of CARA CMC Biologics A/S
Kbenhavn
2005 to 2009
Chief Science Officer Waters Corporation
Milford, MA
Aug 1997 to Sep 2003
Director of Separation Sciences Waters Corporation
Milford, MA
Jan 1993 to Mar 1997
V.P. Separation Technology AutoImmune Inc
Lexington, MA
1993 to 1997
Director Pharmaceutical Development and Quality Control SUNY Health Science Center
Syracuse, NY
Jun 1989 to Jul 1991
Adjunct Assistant Professor Lecturing Sensors in Bioprocess Control
N.Y., N.Y., US
1990 to 1990 Bristol-Myers Squibb Co
Syracuse, NY
1983 to 1989
Principal Scientist, Supported WW Pennwalt Pharmaceutical
Syracuse, NY
Oct 1983 to Oct 1986
Principal Scientist and Group Leader of Automation Merck Sharp and Dohme Research Labs
Rahway, NJ
Oct 1981 to Dec 1983
Senior Research Chemist Merck Sharp and Dohme Research Laboratory
Rahway, NJ
Jun 1981 to Sep 1983
Sr. Research Chemist J.R. Weber
Letters, UK
1980 to 1980 Representative Publications and Presentations
1979 to 1979 W.C. Purdy

1979 to 1979 Biological Sciences

1971 to 1975 The Scripps Research Institute
La Jolla, CA
Visiting Professor Office of Naval Research Global
Arlington, VA
Associate Director Office of Naval Research

Education:

Univ. Utah
Salt Lake City, UT
1980 to 1981
Doctoral McGill Univ
Montral, QC
1976 to 1980
Graduate Studies Univ. Maryland
College Park, MD
1975 to 1976
Graduate Studies research group moved to McGill University
1976
Research Advisor W

License Records

Bruce D Compton

Address:

Marshfield, MA 02050

License #:

9060566 - Expired

Issued Date:

Dec 19, 2003

Expiration Date:

Nov 26, 2006

Type:

Salesperson

Us Patents

Hydraulic Amplifier Pump For Use In Ultrahigh Pressure Liquid Chromatography
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US Patent:

6712587, Mar 30, 2004
Filed:

Dec 21, 2001
Appl. No.:

10/026089
Inventors:

Geoff C. Gerhardt - Milbury MA
Bruce J. Compton - Lexington MA
Assignee:

Waters Investments Limited - Wilmington DE
International Classification:

F04B 1700
US Classification:

417390, 91321, 91275, 91415, 417387, 417388, 417401, 417403
Abstract:

A hydraulic amplifier system for an ultra-high pressure liquid chromatography system. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.

Conjugates Of Agents And Transglutaminase Substrate Linking Molecules
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US Patent:

6919076, Jul 19, 2005
Filed:

Jul 22, 1999
Appl. No.:

09/359920
Inventors:

Howard Green - Brookline MA, US
Bruce Compton - Lexington MA, US
George Corey - Newton MA, US
Philippe Djian - Paris, FR
Assignee:

Pericor Science, Inc. - Boston MA
International Classification:

A61K038/00
A61K038/45
A61K038/48
C12N011/02
C07K017/02
US Classification:

424 945, 424 59, 424 946, 424 9463, 424401, 435 16, 435177, 435193, 435196, 514 2, 530402, 530812
Abstract:

Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the agent is not a transglutaminase substrate and the linking molecule is a substrate for transglutaminase containing at least two contiguous linked glutamines or at least three contiguous linked lysines, and may be a polymer. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule. A complementary linking molecule rich in lysines may be first attached to the tissue in the presence of transglutaminase, and then covalently bonded to a glutamine-containing linking molecule of the conjugate in the presence of transglutaminase. In another embodiment a linking molecule containing multiple glutamines is covalently bonded to tissue in the presence of transglutaminase, and an agent containing multiple lysines is covalently bonded to the linking molecule in the presence of transglutaminase.

Linkage Of Agents To Body Tissue Using Microparticles And Transglutaminase
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US Patent:

6958148, Oct 25, 2005
Filed:

Jul 21, 2000
Appl. No.:

09/620783
Inventors:

Howard Green - Brookline MA, US
Bruce J. Compton - Lexington MA, US
George D. Corey - Newton MA, US
Philippe Djian - Paris, FR
Assignee:

Pericor Science, Inc. - Boston MA
International Classification:

A61K038/45
A61K038/48
A61K038/00
C12N011/02
C07K017/02
US Classification:

424 945, 424 59, 424 9463, 424401, 435 16, 435177, 435193, 514 2, 530402, 530812
Abstract:

Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing at least two contiguous linked lysines or at least three contiguous linked glutamines.

Method For Using A Hydraulic Amplifier Pump In Ultrahigh Pressure Liquid Chromatography
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US Patent:

7311502, Dec 25, 2007
Filed:

Mar 1, 2004
Appl. No.:

10/791080
Inventors:

Geoff C. Gerhardt - Milbury MA, US
Bruce J. Compton - Lexington MA, US
Assignee:

Waters Investments Limited - New Castle DE
International Classification:

F04B 17/00
US Classification:

417390, 91321, 417388
Abstract:

A method for supplying solvent to an ultra-high pressure liquid chromatography system using a hydraulic amplifier. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.

Oral Delivery Formulation
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US Patent:

20030059471, Mar 27, 2003
Filed:

Nov 29, 2001
Appl. No.:

09/997277
Inventors:

Bruce Compton - Lexington MA, US
Nancy Solari - West Newton MA, US
Margaret Flangan - Stow MA, US
International Classification:

A61K009/14
US Classification:

424/489000
Abstract:

Flakes containing drugs and methods for forming and using such flakes are provided.

Methods And Apparatus For Identifying Compounds In A Sample
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US Patent:

20050233464, Oct 20, 2005
Filed:

Apr 6, 2005
Appl. No.:

11/099891
Inventors:

Bruce Compton - Lexington MA, US
Robert Plumb - Milford MA, US
Assignee:

WATERS INVESTMENTS LIMITED - New Castle DE
International Classification:

G01N030/02
US Classification:

436161000, 436173000, 422070000
Abstract:

Embodiments of the present invention provide methods and apparatus for comparing the proteome and or metabonome of an organism or culture to standard values, over time, or after a change has taken place, a pertubation, with respect to the organinsm or culture.

Transglutaminase Linkage Of Agents To Tissue
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US Patent:

20060104966, May 18, 2006
Filed:

Jun 3, 2005
Appl. No.:

11/144372
Inventors:

Howard Green - Brookline MA, US
Bruce Compton - Lexington MA, US
George Corey - Newton MA, US
Philippe Djian - Paris, FR
Assignee:

Pericor Science, Inc. - Boston MA
International Classification:

A61K 38/48
US Classification:

424094500
Abstract:

Methods, products and kits are provided for attaching agents to body tissues using transglutaminase.

Linkage Of Agents Using Microparticles
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US Patent:

20060110379, May 25, 2006
Filed:

May 10, 2005
Appl. No.:

11/125830
Inventors:

Howard Green - Brookline MA, US
Bruce Compton - Lexington MA, US
George Corey - Newton MA, US
Philippe Djian - Paris, FR
Assignee:

Pericor Science, Inc. - Boston MA
International Classification:

A61K 38/48
A61K 9/14
US Classification:

424094500, 424489000, 977906000
Abstract:

Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase.